Any feedback?
Literature summary for 1.8.4.12 extracted from
- Methionine sulfoxide reductases: ubiquitous enzymes involved in antioxidant defense, protein regulation, and prevention of aging-associated diseases (2005), Biochim. Biophys. Acta, 1703, 213-219.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | MsrB expression is induced by heat shock and alkylating methyl-methanesulfonate treatment | Saccharomyces cerevisiae | |
| additional information | expression of MsrB is induced by dehydration and H2O2 | Arabidopsis thaliana |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | H2O2 shortens the life span of cells in constructed null mutants, the mutants show decreased MsrB activity with age compared to the wild-type enzyme | Saccharomyces cerevisiae |
| additional information | H2O2 shortens the life span of cells in constructed null mutants | Escherichia coli |
| additional information | H2O2 shortens the life span of cells in constructed null mutants | Staphylococcus aureus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | selenium-adequate diet retains MsrB mRNA and protein expression at basal levels | Mus musculus | |
| additional information | selenium-adequate diet retains MsrB mRNA and protein expression at basal levels | Sus scrofa |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-methionine (R)-sulfoxide + thioredoxin | Mus musculus | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? |  |
| L-methionine (R)-sulfoxide + thioredoxin | Saccharomyces cerevisiae | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| L-methionine (R)-sulfoxide + thioredoxin | Escherichia coli | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| L-methionine (R)-sulfoxide + thioredoxin | Staphylococcus aureus | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| L-methionine (R)-sulfoxide + thioredoxin | Arabidopsis thaliana | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| L-methionine (R)-sulfoxide + thioredoxin | Sus scrofa | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| L-methionine (R)-sulfoxide + thioredoxin | Homo sapiens | MsrB is specific for the R-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| additional information | Mus musculus | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview, oxidation of 2 essential methionine residues of HIV-2 particles can inactivate the virus and prevent infection of human cells | ? | - |
? | |
| additional information | Saccharomyces cerevisiae | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview | ? | - |
? | |
| additional information | Escherichia coli | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview | ? | - |
? | |
| additional information | Staphylococcus aureus | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview | ? | - |
? | |
| additional information | Arabidopsis thaliana | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins | ? | - |
? | |
| additional information | Sus scrofa | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview | ? | - |
? | |
| additional information | Homo sapiens | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | - |
- |
- |
| Escherichia coli | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Staphylococcus aureus | - |
- |
- |
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| brain | - |
Homo sapiens | - |
| kidney | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
| lung | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Mus musculus | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Saccharomyces cerevisiae | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Escherichia coli | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Staphylococcus aureus | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Arabidopsis thaliana | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Sus scrofa | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the R-form | Homo sapiens | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| additional information | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview, oxidation of 2 essential methionine residues of HIV-2 particles can inactivate the virus and prevent infection of human cells | Mus musculus | ? | - |
? | |
| additional information | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview | Saccharomyces cerevisiae | ? | - |
? | |
| additional information | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview | Escherichia coli | ? | - |
? | |
| additional information | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview | Staphylococcus aureus | ? | - |
? | |
| additional information | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins | Arabidopsis thaliana | ? | - |
? | |
| additional information | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview | Sus scrofa | ? | - |
? | |
| additional information | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| methionine sulfoxide reductase | - |
Mus musculus |
| methionine sulfoxide reductase | - |
Saccharomyces cerevisiae |
| methionine sulfoxide reductase | - |
Escherichia coli |
| methionine sulfoxide reductase | - |
Staphylococcus aureus |
| methionine sulfoxide reductase | - |
Arabidopsis thaliana |
| methionine sulfoxide reductase | - |
Sus scrofa |
| methionine sulfoxide reductase | - |
Homo sapiens |
| MsrB | - |
Mus musculus |
| MsrB | - |
Saccharomyces cerevisiae |
| MsrB | - |
Escherichia coli |
| MsrB | - |
Staphylococcus aureus |
| MsrB | - |
Arabidopsis thaliana |
| MsrB | - |
Sus scrofa |
| MsrB | - |
Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| thioredoxin | - |
Mus musculus | |
| thioredoxin | - |
Saccharomyces cerevisiae | |
| thioredoxin | - |
Escherichia coli | |
| thioredoxin | - |
Staphylococcus aureus | |
| thioredoxin | - |
Arabidopsis thaliana | |
| thioredoxin | - |
Sus scrofa | |
| thioredoxin | - |
Homo sapiens | |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2026.1 (March 2026)
Legal
Curated at
Member of
![DSMZ Digital Diversity]()
![Global Core Biodata Resource]()
![ELIXIR Core Data Resource]()
![German Network for Bioinformatics Infrastructure]()
