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Literature summary for 1.8.4.12 extracted from

  • Kryukov, G.V.; Kumar, R.A.; Koc, A.; Sun, Z.; Gladyshev, V.N.
    Selenoprotein R is a zinc-containing stereo-specific methionine sulfoxide reductase (2002), Proc. Natl. Acad. Sci. USA, 99, 4245-4250.
    View publication on PubMed
Search for more literature for 1.8.4.12

Cloned(Commentary)

Cloned (Comment) Organism
gene selR, DNA and amino acid sequence determination and analysis, expression as His-tagged enzyme in Escherichia coli strain BL21(DE3) Drosophila melanogaster
overexpression of wild-type and mutant enzymes in Escherichia coli strain BL21(DE3) Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
selenium selenoprotein Drosophila melanogaster
selenium selenoprotein Mus musculus
Zn2+ metalloenzyme, content determination Drosophila melanogaster
Zn2+ metalloenzyme, content determination Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-methionine (R)-sulfoxide + thioredoxin Mus musculus MsrB is absolute specific for the R-form, no activity with the S-form, pathway overview L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine (R)-sulfoxide + thioredoxin Drosophila melanogaster MsrB is absolute specific for the R-form, no activity with the S-form, pathway overview L-methionine + thioredoxin disulfide + H2O
-
 ?
additional information Mus musculus enzyme provides protection for the cell against oxidative stress ?
-
 ?
additional information Drosophila melanogaster enzyme provides protection for the cell against oxidative stress ?
-
 ?

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster Q8INK9
-
-
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant His-tagged enzyme from Escherichia coli strain BL21(DE3) Drosophila melanogaster
recombinant wild-type and mutant enzymes from Escherichia coli strain BL21(DE3) by heparin affinity chromatography Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-methionine (R)-sulfoxide + thioredoxin MsrB is absolute specific for the R-form, no activity with the S-form, pathway overview Mus musculus L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine (R)-sulfoxide + thioredoxin MsrB is absolute specific for the R-form, no activity with the S-form, pathway overview Drosophila melanogaster L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine (R)-sulfoxide + thioredoxin MsrB is absolute specific for the R-form, no activity with the S-form Mus musculus L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine (R)-sulfoxide + thioredoxin MsrB is absolute specific for the R-form, no activity with the S-form Drosophila melanogaster L-methionine + thioredoxin disulfide + H2O
-
 ?
additional information enzyme provides protection for the cell against oxidative stress Mus musculus ?
-
 ?
additional information enzyme provides protection for the cell against oxidative stress Drosophila melanogaster ?
-
 ?

Synonyms

Synonyms Comment Organism
methionine-R-sulfoxide reductase
-
 Mus musculus
methionine-R-sulfoxide reductase
-
 Drosophila melanogaster
selenoprotein R
-
 Mus musculus
selenoprotein R
-
 Drosophila melanogaster
SelR
-
 Mus musculus
SelR
-
 Drosophila melanogaster

Cofactor

Cofactor Comment Organism Structure
thioredoxin
-
 Mus musculus
thioredoxin
-
 Drosophila melanogaster