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Literature summary for 1.8.4.12 extracted from
- Multiple methionine sulfoxide reductase genes in Staphylococcus aureus: expression of activity and roles in tolerance of oxidative stress (2003), Microbiology, 149, 2739-2747.
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-methionine (R)-sulfoxide + thioredoxin | Staphylococcus aureus | MsrB is specific for the (R)-form of the substrate | L-methionine + thioredoxin disulfide + H2O | - |
? |  |
| additional information | Staphylococcus aureus | the MsrA1/MsrB system is physiologically more significant in Staphylococcus aureus than MsrA2 | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Staphylococcus aureus | - |
strains RN450 and BB270, and derivatives, 1 gene msrB | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.000029 | - |
wild-type strain RN450, substrate L-methionine (R)-sulfoxide | Staphylococcus aureus |
| 0.00003 | - |
msrA2 knockout strain RN450, substrate L-methionine (R)-sulfoxide | Staphylococcus aureus |
| 0.0012 | - |
msrA1 knockout strain RN450, substrate L-methionine (R)-sulfoxide | Staphylococcus aureus |
| 0.0015 | - |
msrA1/msrA2 double knockout strain RN450, substrate L-methionine (R)-sulfoxide | Staphylococcus aureus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-methionine (R)-sulfoxide + thioredoxin | MsrB is specific for the (R)-form of the substrate | Staphylococcus aureus | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| additional information | the MsrA1/MsrB system is physiologically more significant in Staphylococcus aureus than MsrA2 | Staphylococcus aureus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| methionine sulfoxide reductase | - |
Staphylococcus aureus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Staphylococcus aureus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Staphylococcus aureus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| thioredoxin | - |
Staphylococcus aureus | |
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