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Literature summary for 1.8.4.12 extracted from
- Reduction of Sulindac to its active metabolite, sulindac sulfide: assay and role of the methionine sulfoxide reductase system (2003), Biochem. Biophys. Res. Commun., 312, 1005-1010.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | membrane-associated enzyme MsrB | Escherichia coli | 16020 | - |
| membrane | - |
Bos taurus | 16020 | - |
| microsome | - |
Escherichia coli | - |
- |
| microsome | - |
Bos taurus | - |
- |
| mitochondrion | - |
Escherichia coli | 5739 | - |
| mitochondrion | - |
Bos taurus | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| sulindac + thioredoxin | Escherichia coli | activation of the antiinflammatory drug with anti-tumorigenic activity, which acts via inhibition of cyclooxygenases 1 and 2 | sulindac sulfide + thioredoxin disulfide + H2O | - |
? |  |
| sulindac + thioredoxin | Bos taurus | - |
sulindac sulfide + thioredoxin disulfide + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
calf | - |
| Escherichia coli | - |
enzyme forms MsrB, and other enzyme forms, e.g. Mem-R,S-Msr, overview | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partially, cell fragmentation | Bos taurus |
| recombinant MsrB | Escherichia coli |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Bos taurus | - |
| kidney | highest sulindac reductase activity | Bos taurus | - |
| liver | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.000085 | - |
enzyme form Mem-R,S-Msr | Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | substrate specificity of enzyme forms with R-form of free and protein-bound methionine sulfoxide, overview | Escherichia coli | ? | - |
? | |
| sulindac + thioredoxin | activation of the antiinflammatory drug with anti-tumorigenic activity, which acts via inhibition of cyclooxygenases 1 and 2 | Escherichia coli | sulindac sulfide + thioredoxin disulfide + H2O | - |
? | |
| sulindac + thioredoxin | - |
Bos taurus | sulindac sulfide + thioredoxin disulfide + H2O | - |
? | |
| sulindac + thioredoxin | highest activity by a membrane bound enzyme form Mem-R,S-Msr, which preferentially reduces the R-substrate form, no activity by enzyme forms fRMsr, fSMsr, low activity by enzyme forms MsrB | Escherichia coli | sulindac sulfide + thioredoxin disulfide + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| methionine sulfoxide reductase | - |
Bos taurus |
| sulindac reductase | - |
Bos taurus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Bos taurus |
| 37 | - |
assay at | Escherichia coli |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Escherichia coli |
| 7.4 | - |
assay at | Bos taurus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| thioredoxin | - |
Escherichia coli | |
| thioredoxin | - |
Bos taurus | |
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