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Literature summary for 1.8.4.11 extracted from
- The repair enzyme peptide methionine-S-sulfoxide reductase is expressed in human epidermis and upregulated by UVA radiation (2006), J. Invest. Dermatol., 126, 1128-1134.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | MsrA is upregulated by UVA radiation in keratinocytes | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| peptide-L-methionine-(S)-S-oxide + thioredoxin | Homo sapiens | the enzyme protects the epidermis cells against irradiation and oxidative damages, overview | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
female caucasian individuals | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| epidermis | - |
Homo sapiens | - |
| HaCaT cell | primary keratinocytes, expression level at normal light and UV-light conditions | Homo sapiens | - |
| skin | accumulation in the upper dermis | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| His6-Ala-Ala-Gln-MetO-Ile + DTT | - |
Homo sapiens | His6-Ala-Ala-Gln-Met-Ile + DTT disulfide + H2O | - |
? | |
| peptide-L-methionine-(S)-S-oxide + thioredoxin | the enzyme protects the epidermis cells against irradiation and oxidative damages, overview | Homo sapiens | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
| peptide-L-methionine-(S)-S-oxide + thioredoxin | stereospecific reduction | Homo sapiens | peptide-L-methionine + thioredoxin disulfide + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| MsrA | - |
Homo sapiens |
| peptide methionine S-sulfoxide reductase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| dithiothreitol | - |
Homo sapiens | |
| thioredoxin | - |
Homo sapiens | |
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