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Literature summary for 1.8.4.11 extracted from
- Methionine sulfoxide reductases: ubiquitous enzymes involved in antioxidant defense, protein regulation, and prevention of aging-associated diseases (2005), Biochim. Biophys. Acta, 1703, 213-219.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | MsrA expression and enzyme formation is induced in the stationary growth phase or on starvation for amino acids, glucose, or nitrogen | Escherichia coli | |
| additional information | MsrA expression is induced by oxidizing diamide treatment and gamma-irradiation, the factor calcium-phosphate-binding protein CPBP, a homologue of elongation factor 1-gamma participates in transcription of gene msrA as part of a transcription regulation complex | Saccharomyces cerevisiae | |
| additional information | oxacillin induces MsrA expression and enzyme formation | Staphylococcus aureus |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | construction of a MsrA null mutant which exhibits a neurological disorder in the form of ataxia, is more sensitive to oxidative stress, and has by about 40% shorter life span than the wild-type mice at normal oxygen conditions and 10% at hyperoxic conditions | Mus musculus |
| additional information | H2O2 shortens the life span of cells in constructed null mutants | Staphylococcus aureus |
| additional information | H2O2 shortens the life span of cells in constructed null mutants | Escherichia coli |
| additional information | H2O2 shortens the life span of cells in constructed null mutants | Saccharomyces cerevisiae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-methionine (S)-sulfoxide + thioredoxin | Staphylococcus aureus | MsrA is specific for the S-form | L-methionine + thioredoxin disulfide + H2O | - |
? |  |
| L-methionine (S)-sulfoxide + thioredoxin | Mus musculus | MsrA is specific for the S-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| L-methionine (S)-sulfoxide + thioredoxin | Escherichia coli | MsrA is specific for the S-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| L-methionine (S)-sulfoxide + thioredoxin | Homo sapiens | MsrA is specific for the S-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| L-methionine (S)-sulfoxide + thioredoxin | Sus scrofa | MsrA is specific for the S-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| L-methionine (S)-sulfoxide + thioredoxin | Saccharomyces cerevisiae | MsrA is specific for the S-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| L-methionine (S)-sulfoxide + thioredoxin | Arabidopsis thaliana | MsrA is specific for the S-form | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| additional information | Arabidopsis thaliana | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins | ? | - |
? | |
| additional information | Homo sapiens | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrA has several different physiological repair and regulatory functions, overview | ? | - |
? | |
| additional information | Sus scrofa | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrA has several different physiological repair and regulatory functions, overview | ? | - |
? | |
| additional information | Mus musculus | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, MsrA can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview, oxidation of 2 essential methionine residues of HIV-2 particles can inactivate the virus and prevent infection of human cells | ? | - |
? | |
| additional information | Staphylococcus aureus | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrA has several different physiological repair and regulatory functions, overview | ? | - |
? | |
| additional information | Escherichia coli | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrA has several different physiological repair and regulatory functions, overview | ? | - |
? | |
| additional information | Saccharomyces cerevisiae | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrA has several different physiological repair and regulatory functions, overview | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | - |
- |
- |
| Escherichia coli | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
| Staphylococcus aureus | - |
- |
- |
| Sus scrofa | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| brain | - |
Homo sapiens | - |
| kidney | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
| lung | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form | Staphylococcus aureus | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form | Mus musculus | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form | Escherichia coli | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form | Homo sapiens | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form | Sus scrofa | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form | Saccharomyces cerevisiae | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| L-methionine (S)-sulfoxide + thioredoxin | MsrA is specific for the S-form | Arabidopsis thaliana | L-methionine + thioredoxin disulfide + H2O | - |
? | |
| additional information | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins | Arabidopsis thaliana | ? | - |
? | |
| additional information | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrA has several different physiological repair and regulatory functions, overview | Homo sapiens | ? | - |
? | |
| additional information | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrA has several different physiological repair and regulatory functions, overview | Sus scrofa | ? | - |
? | |
| additional information | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging and age-related diseases, MsrA can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrB has several different physiological repair and regulatory functions, overview, oxidation of 2 essential methionine residues of HIV-2 particles can inactivate the virus and prevent infection of human cells | Mus musculus | ? | - |
? | |
| additional information | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrA has several different physiological repair and regulatory functions, overview | Staphylococcus aureus | ? | - |
? | |
| additional information | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrA has several different physiological repair and regulatory functions, overview | Escherichia coli | ? | - |
? | |
| additional information | recycling of free methionine, enzyme reverses the oxidative damage at methionine protein residues oxidized to methionine sulfoxide being a major cause of aging, Msr can regulate protein function, be involved in signal transduction, and prevent accumulation of faulty proteins, MsrA has several different physiological repair and regulatory functions, overview | Saccharomyces cerevisiae | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| methionine sulfoxide reductase | - |
Staphylococcus aureus |
| methionine sulfoxide reductase | - |
Mus musculus |
| methionine sulfoxide reductase | - |
Escherichia coli |
| methionine sulfoxide reductase | - |
Homo sapiens |
| methionine sulfoxide reductase | - |
Sus scrofa |
| methionine sulfoxide reductase | - |
Saccharomyces cerevisiae |
| methionine sulfoxide reductase | - |
Arabidopsis thaliana |
| MsrA | - |
Staphylococcus aureus |
| MsrA | - |
Mus musculus |
| MsrA | - |
Escherichia coli |
| MsrA | - |
Homo sapiens |
| MsrA | - |
Sus scrofa |
| MsrA | - |
Saccharomyces cerevisiae |
| MsrA | - |
Arabidopsis thaliana |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| thioredoxin | - |
Staphylococcus aureus | |
| thioredoxin | - |
Mus musculus | |
| thioredoxin | - |
Escherichia coli | |
| thioredoxin | - |
Homo sapiens | |
| thioredoxin | - |
Sus scrofa | |
| thioredoxin | - |
Saccharomyces cerevisiae | |
| thioredoxin | - |
Arabidopsis thaliana | |
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Release 2023.1 (January 2023)
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