Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.8.4.11 extracted from

  • Vougier, S.; Mary, J.; Friguet, B.
    Subcellular localization of methionine sulphoxide reductase A (MsrA): evidence for mitochondrial and cytosolic isoforms in rat liver cells (2003), Biochem. J., 373, 531-537.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 1.8.4.11

Cloned(Commentary)

Cloned (Comment) Organism
mitochondrial and cytosolic isozymes are encoded by a single gene Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol cytosolic isozyme of MsrA Rattus norvegicus 5829
-
mitochondrion matrix, mitochondrial isozyme of MsrA Rattus norvegicus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protein-L-methionine (S)-sulfoxide + thioredoxin Rattus norvegicus MsrA is specific for the S-form, enzyme provides protection against oxidative damage by reactive oxygen species and has a repair function for oxidized protein methionine residues protein-L-methionine + thioredoxin disulfide + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 2 isozymes of MsrA
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification enzyme precursor contains a cleavable N-terminal signal sequence for targeting to the mitochondria Rattus norvegicus

Purification (Commentary)

Purification (Comment) Organism
MsrA from cytosolic and mitochondrial fractions Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0002
-
 cytosol, overall Msr activity, substrate is a mixture of S- and R-form of dabsyl L-methionine sulfoxide Rattus norvegicus
0.00021
-
 mitochondria, overall Msr activity, substrate is a mixture of S- and R-form of dabsyl L-methionine sulfoxide Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dabsyl-L-methionine (S)-sulfoxide + thioredoxin synthetic substrate Rattus norvegicus dabsyl-L-methionine + thioredoxin disulfide + H2O
-
 ?
protein-L-methionine (S)-sulfoxide + thioredoxin MsrA is specific for the S-form Rattus norvegicus protein-L-methionine + thioredoxin disulfide + H2O
-
 ?
protein-L-methionine (S)-sulfoxide + thioredoxin MsrA is specific for the S-form, enzyme provides protection against oxidative damage by reactive oxygen species and has a repair function for oxidized protein methionine residues Rattus norvegicus protein-L-methionine + thioredoxin disulfide + H2O
-
 ?

Synonyms

Synonyms Comment Organism
methionine sulphoxide reductase A
-
 Rattus norvegicus
MsrA
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
thioredoxin
-
 Rattus norvegicus