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Literature summary for 1.8.4.11 extracted from

  • Dhandayuthapani, S.; Blaylock, M.W.; Bebear, C.M.; Rasmussen, W.G.; Baseman, J.B.
    Peptide methionine sulfoxide reductase (MsrA) is a virulence determinant in Mycoplasma genitalium (2001), J. Bacteriol., 183, 5645-5650.
    View publication on PubMed
Search for more literature for 1.8.4.11

Cloned(Commentary)

Cloned (Comment) Organism
overexpression of His10-tagged MsrA in Escherichia coli strain BL21(DE3) Mycoplasmoides genitalium

Protein Variants

Protein Variants Comment Organism
additional information msrA disruption mutants, constructed by insertion mutagenesis, show highly increased sensitivity to H2O2 and reduced capability to adhere to host cell surfaces for infection, overview Mycoplasmoides genitalium

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mycoplasmoides genitalium MsrA is a virulence determinant for the plant pathogen required for full virulence ?
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin Mycoplasmoides genitalium stereospecific reduction of protein-bound methionine (S)-sulfoxide residues, the enzyme is involved in repair of oxidized proteins by reducing oxidized methionine residues, which is required for resistance to hydrogen peroxide and other reactive oxygen species, and for adherence to host cell surfaces peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Mycoplasmoides genitalium
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-
-

Purification (Commentary)

Purification (Comment) Organism
recombinant His10-tagged MsrA from Escherichia coli strain BL21(DE3) by nickel affinity chromatography Mycoplasmoides genitalium

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information MsrA is a virulence determinant for the plant pathogen required for full virulence Mycoplasmoides genitalium ?
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction of protein-bound methionine (S)-sulfoxide residues, the enzyme is involved in repair of oxidized proteins by reducing oxidized methionine residues, which is required for resistance to hydrogen peroxide and other reactive oxygen species, and for adherence to host cell surfaces Mycoplasmoides genitalium peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction of protein-bound methionine (S)-sulfoxide residues Mycoplasmoides genitalium peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?

Synonyms

Synonyms Comment Organism
MsrA
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 Mycoplasmoides genitalium
peptide methionine sulfoxide reductase
-
 Mycoplasmoides genitalium

Cofactor

Cofactor Comment Organism Structure
thioredoxin
-
 Mycoplasmoides genitalium