Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.8.4.11 extracted from

  • Brot, N.; Weissbach, L.; Werth, J.; Weissbach, H.
    Enzymatic reduction of protein-bound methionine sulfoxide (1981), Proc. Natl. Acad. Sci. USA, 78, 2155-2158.
    View publication on PubMed
Search for more literature for 1.8.4.11

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ activates Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peptide-L-methionine-(S)-S-oxide + thioredoxin Escherichia coli substrate is oxidized ribosomal L12 protein, stereospecific reduction peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin Escherichia coli Z19 substrate is oxidized ribosomal L12 protein, stereospecific reduction peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
Tyr-Gly-Gly-Phe-L-methionine-(S)-S-oxide + thioredoxin Escherichia coli oxidized Met-enkephalin Tyr-Gly-Gly-Phe-L-methionine + thioredoxin disulfide + H2O
-
 ?
Tyr-Gly-Gly-Phe-L-methionine-(S)-S-oxide + thioredoxin Escherichia coli Z19 oxidized Met-enkephalin Tyr-Gly-Gly-Phe-L-methionine + thioredoxin disulfide + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli Z19
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme by ammonium sulfate fractionation, dialysis, anion exchange chromatography, and gel filtration Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
peptide-L-methionine-(S)-S-oxide + DTT protein-bound substrate, stereospecific reduction, substrate is oxidized ribosomal L12 protein Escherichia coli peptide-L-methionine + DTT disulfide + H2O
-
 ?
peptide-L-methionine-(S)-S-oxide + DTT protein-bound substrate, stereospecific reduction, substrate is oxidized ribosomal L12 protein Escherichia coli Z19 peptide-L-methionine + DTT disulfide + H2O
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin substrate is oxidized ribosomal L12 protein, stereospecific reduction Escherichia coli peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin protein-bound substrate, stereospecific reduction, substrates are oxidized ribosomal L12 protein or oxidized Met-enkephalin Escherichia coli peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin substrate is oxidized ribosomal L12 protein, stereospecific reduction Escherichia coli Z19 peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin protein-bound substrate, stereospecific reduction, substrates are oxidized ribosomal L12 protein or oxidized Met-enkephalin Escherichia coli Z19 peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?
Tyr-Gly-Gly-Phe-L-methionine-(S)-S-oxide + DTT oxidized Met-enkephalin Escherichia coli Tyr-Gly-Gly-Phe-L-methionine + DTT disulfide + H2O
-
 ?
Tyr-Gly-Gly-Phe-L-methionine-(S)-S-oxide + DTT oxidized Met-enkephalin Escherichia coli Z19 Tyr-Gly-Gly-Phe-L-methionine + DTT disulfide + H2O
-
 ?
Tyr-Gly-Gly-Phe-L-methionine-(S)-S-oxide + thioredoxin oxidized Met-enkephalin Escherichia coli Tyr-Gly-Gly-Phe-L-methionine + thioredoxin disulfide + H2O
-
 ?
Tyr-Gly-Gly-Phe-L-methionine-(S)-S-oxide + thioredoxin oxidized Met-enkephalin Escherichia coli Z19 Tyr-Gly-Gly-Phe-L-methionine + thioredoxin disulfide + H2O
-
 ?

Synonyms

Synonyms Comment Organism
MetSO-L12 reductase
-
 Escherichia coli

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Escherichia coli

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Escherichia coli

Cofactor

Cofactor Comment Organism Structure
dithiothreitol
-
 Escherichia coli
thioredoxin
-
 Escherichia coli