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Literature summary for 1.8.4.11 extracted from

  • Moskovitz, J.; Bar-Noy, S.; Williams, W.M.; Requena, J.; Berlett, B.S.; Stadtman, E.R.
    Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals (2001), Proc. Natl. Acad. Sci. USA, 98, 12920-12925.
    View publication on PubMed
Search for more literature for 1.8.4.11

Protein Variants

Protein Variants Comment Organism
additional information generation of MsrA-deficient mutant mice, the mutant mice show tip-toe-walking, reduced lifespan under hyperoxic conditions and increased sensitivity to oxidative stress compared to wild-type mice, phenotype overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-methionine-(S)-S-oxide + thioredoxin Mus musculus stereospecific reduction L-methionine + thioredoxin disulfide + H2O
-
 ?
additional information Mus musculus MsrA is a regulator of antioxidant defense and lifespan in mammals ?
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin Mus musculus stereospecific reduction peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL76J mice, gene msrA
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
kidney
-
 Mus musculus
-
liver
-
 Mus musculus
-
lung
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 activities in wild-type and mutant mice in different organs during 2 days, overview Mus musculus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dabsyl-L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Mus musculus dabsyl-L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Mus musculus L-methionine + thioredoxin disulfide + H2O
-
 ?
L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction, free methionine-(S)-S-oxide Mus musculus L-methionine + thioredoxin disulfide + H2O
-
 ?
additional information MsrA is a regulator of antioxidant defense and lifespan in mammals Mus musculus ?
-
 ?
peptide-L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Mus musculus peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?

Synonyms

Synonyms Comment Organism
methionine sulfoxide reductase
-
 Mus musculus
MsrA
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
thioredoxin
-
 Mus musculus