Application | Comment | Organism |
---|---|---|
diagnostics | QSOX1 is a potential prognostic marker which may prove of use in the staging of breast tumours and the stratification of breast cancer patients | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
gene QSOX1, DNA and amino acid sequence determination and analysis, quantitative real-time PCR enzyme expression analysis, two putative alternative splicing variants might contribute to the differences in expression level between exon 7 and the 3'UTR are QSOX1d and QSOX1e. In QSOX1d the thioredoxin TRX1 domain remains intact, whilst the TRX2 and HRR domains are removed completely, making these isoforms similar to plant QSOXs which lack the second Trx domain but have the same three redox sites. TRX1 is truncated at its C-terminus in QSOX1e and both of the splicing | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00391 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell | expression analysis of a panel of cDNAs derived from 50 clinically-graded normal and malignant breast tissue samples for the expression of QSOX1 mRNAs, significant correlation between relative transcript level and clinical grade malignant breast tumors | Homo sapiens | - |
T-47D cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
QSOx1 | - |
Homo sapiens |
quiescin Q6 sulfhydryl oxidase 1 | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | the enzyme belongs to a family of flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidases | Homo sapiens |