Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-chloro-2,4-dinitrobenzene | - |
Haemonchus contortus | |
2,2'-(ethane-1,2-diyl)di(1,2-benzoselenazol-3(2H)-one) | IC50 value for HEK-293T cells 3.4 microg/ml | Escherichia coli | |
2,2'-(hexane-1,6-diyl)di(1,2-benzoselenazol-3(2H)-one) | IC50 value for HEK-293T cells 2.5 microg/ml | Escherichia coli | |
auranofin | 15 nM, complete inhibition | Haemonchus contortus | |
ebselen | competitive, inhibitor reacts with the active site dithiol | Escherichia coli |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0025 | - |
ebsulfur | pH 7.5, temperature not specified in the publication | Escherichia coli | |
0.006 | - |
NADPH | pH 7.8, 37°C | Haemonchus contortus | |
0.0275 | - |
ebsulfur disulfide | pH 7.5, temperature not specified in the publication | Escherichia coli | |
0.28 | - |
5,5'-dithio-bis(2-nitrobenzoic acid) | pH 7.8, 37°C | Haemonchus contortus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
134000 | - |
gel filtration | Haemonchus contortus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Haemonchus contortus | - |
thioredoxin reductase with additional glutathione reductase, EC 1.8.1.7, activity | - |
Purification (Comment) | Organism |
---|---|
- |
Haemonchus contortus |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.044 | - |
substrate S-nitrosoglutathione, pH 7.8, 37°C | Haemonchus contortus |
0.068 | - |
substrate sodium selenite, pH 7.8, 37°C | Haemonchus contortus |
0.495 | - |
substrate ebselen, pH 7.8, 37°C | Haemonchus contortus |
6 | - |
substrate 5,5'-dithio-bis(2-nitrobenzoic acid), pH 7.8, 37°C | Haemonchus contortus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,5'-dithio-bis(2-nitrobenzoic acid) + NADPH + H+ | - |
Haemonchus contortus | 5'-thionitrobenzoic acid + NADP+ | - |
? | |
ebselen + NADPH + H+ | - |
Haemonchus contortus | ? + NADP+ | - |
? | |
ebsulfur + NADP+ | - |
Escherichia coli | ebsulfur disulfide + NADPH + H+ | - |
? | |
ebsulfur disulfide + NADPH + H+ | - |
Escherichia coli | ebsulfur + NADP+ | - |
r | |
S-nitrosoglutathione + NADPH + H+ | - |
Haemonchus contortus | ? + NADP+ | - |
? | |
sodium selenite + NADPH + H+ | - |
Haemonchus contortus | ? + NADP+ | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 67000, SDS-PAGE | Haemonchus contortus |
Synonyms | Comment | Organism |
---|---|---|
HCOI_01258400 | - |
Haemonchus contortus |
TrxR3 | - |
Haemonchus contortus |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
40 | - |
- |
Haemonchus contortus |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
stable for 20 min | Haemonchus contortus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.7 | - |
ebsulfur disulfide | pH 7.5, temperature not specified in the publication | Escherichia coli | |
7.1 | - |
NADPH | pH 7.8, 37°C | Haemonchus contortus | |
11.7 | - |
ebsulfur | pH 7.5, temperature not specified in the publication | Escherichia coli | |
11.96 | - |
5,5'-dithio-bis(2-nitrobenzoic acid) | pH 7.8, 37°C | Haemonchus contortus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Haemonchus contortus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Escherichia coli | |
NADPH | - |
Haemonchus contortus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00001 | - |
2,2'-(hexane-1,6-diyl)di(1,2-benzoselenazol-3(2H)-one) | pH 7.5, temperature not specified in the publication | Escherichia coli | |
0.00005 | - |
2,2'-(ethane-1,2-diyl)di(1,2-benzoselenazol-3(2H)-one) | pH 7.5, temperature not specified in the publication | Escherichia coli | |
0.00052 | - |
ebselen | pH 7.5, temperature not specified in the publication | Escherichia coli |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.00225 | - |
pH 7.8, 37°C | Haemonchus contortus | 1-chloro-2,4-dinitrobenzene |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
42 | - |
5,5'-dithio-bis(2-nitrobenzoic acid) | pH 7.8, 37°C | Haemonchus contortus | |
60.5 | - |
ebsulfur disulfide | pH 7.5, temperature not specified in the publication | Escherichia coli | |
470 | - |
ebsulfur | pH 7.5, temperature not specified in the publication | Escherichia coli | |
1170 | - |
NADPH | pH 7.8, 37°C | Haemonchus contortus |