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Literature summary for 1.8.1.9 extracted from

  • Qin, H.; Liang, W.; Xu, Z.; Ye, F.; Li, X.; Zhong, L.
    Mechanistic insights into the inhibitory effects of palmitoylation on cytosolic thioredoxin reductase and thioredoxin (2015), Biochimie, 110, 25-35 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
palmitoyl-CoA covalent inhibition of TrxR1/hTrx1 by palmitoyl-CoA. The palmitoyl-CoA/TrxR1 reaction is NADPH-dependent and produces palmitoylated TrxR1 at an active site selenocysteine residue Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16881
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
side-chain modification enhanced TrxR1/thioredoxin palmitoylation occurs in parallel with a decrease in their activities. Palmitoylated TrxR1/thioredoxin is mainly generated by autoacylation Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
TrxR1
-
Homo sapiens

General Information

General Information Comment Organism
physiological function HepG2 cells utilize cytosolic thioredoxin reductase TrxR1 and thioredoxin to defend against the high glucose/palmitate-mediated increase in reactive oxygen species. Enhanced TrxR1/thioredoxin palmitoylation occurs in parallel with a decrease in their activities Homo sapiens