Inhibitors | Comment | Organism | Structure |
---|---|---|---|
palmitoyl-CoA | covalent inhibition of TrxR1/hTrx1 by palmitoyl-CoA. The palmitoyl-CoA/TrxR1 reaction is NADPH-dependent and produces palmitoylated TrxR1 at an active site selenocysteine residue | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16881 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
side-chain modification | enhanced TrxR1/thioredoxin palmitoylation occurs in parallel with a decrease in their activities. Palmitoylated TrxR1/thioredoxin is mainly generated by autoacylation | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
TrxR1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | HepG2 cells utilize cytosolic thioredoxin reductase TrxR1 and thioredoxin to defend against the high glucose/palmitate-mediated increase in reactive oxygen species. Enhanced TrxR1/thioredoxin palmitoylation occurs in parallel with a decrease in their activities | Homo sapiens |