Inhibitors | Comment | Organism | Structure |
---|---|---|---|
auranofin | - |
Haemonchus contortus | |
curcumin | - |
Haemonchus contortus | |
theaflavin | - |
Haemonchus contortus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | isoform TrxR1 | Haemonchus contortus | 5737 | - |
mitochondrion | isoform TrxR2 | Haemonchus contortus | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
selenium | TrxR1 contains a selenocysteine in the active site (Gly-Cys-SeCys-Gly) | Haemonchus contortus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Haemonchus contortus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5,5'-dithiobis(2-nitrobenzoic acid) + NADPH + H+ | - |
Haemonchus contortus | 2-nitro-5-thiobenzoate + NADP+ | - |
? | |
additional information | isoform TrxR1 shows broad activity with thioredoxins from Escherichia coli, sheep, and Haemonchus contortus, while isoform TrxR2 has high activity only with the mitochondrial Haemonchus contortus thioredoxin | Haemonchus contortus | ? | - |
? | |
selenite + NADPH + H+ | - |
Haemonchus contortus | ? + NADP+ | - |
? | |
thioredoxin disulfide + NADPH + H+ | - |
Haemonchus contortus | thioredoxin + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
thioredoxin reductase | - |
Haemonchus contortus |
TrxR1 | isoform | Haemonchus contortus |
TrxR2 | isoform | Haemonchus contortus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Haemonchus contortus | |
NADPH | - |
Haemonchus contortus |