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Literature summary for 1.8.1.9 extracted from
- In vivo and in vitro inhibition of mice thioredoxin reductase by methylmercury (2010), Biometals, 23, 1171-1177.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| methylmercury | a single administration of methylmercury (1, 5, and 10 mg/kg) causes a marked inhibition of kidney TrxR activity, while significant inhibition is observed in the liver 24 h after exposure to 5 and 10 mg/kg. In the brain, methylmercury does not inhibit TrxR activity. Methylmercury can bind to selenocysteine residues present in the catalytic site of TrxR, in turn causing enzyme inhibition that can compromise the redox state of cells | Mus musculus |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thioredoxin disulfide + NADPH + H+ | Mus musculus | - |
thioredoxin + NADP+ | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Mus musculus | - |
| kidney | - |
Mus musculus | - |
| liver | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thioredoxin disulfide + NADPH + H+ | - |
Mus musculus | thioredoxin + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| thioredoxin reductase | - |
Mus musculus |
| TrxR | - |
Mus musculus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | - |
Mus musculus | |
| NADPH | - |
Mus musculus | |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.0000171 | - |
TrxR from liver, pH and temperature not specified in the publication | Mus musculus | methylmercury | |
| 0.000078 | - |
TrxR from kidney, pH and temperature not specified in the publication | Mus musculus | methylmercury | |
| 0.000158 | - |
TrxR from brain, pH and temperature not specified in the publication | Mus musculus | methylmercury | |
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