Literature summary for 1.8.1.9 extracted from

Chew, E.H.; Nagle, A.A.; Zhang, Y.; Scarmagnani, S.; Palaniappan, P.; Bradshaw, T.D.; Holmgren, A.; Westwell, A.D.
Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention (2010), Free Radic. Biol. Med., 48, 98-111.

Search for more literature for 1.8.1.9

Inhibitors

Inhibitors	Comment	Organism	Structure
2-benzoyloxycinnamaldehyde	-	Escherichia coli
2-benzoyloxycinnamaldehyde	-	Homo sapiens
2-benzoyloxycinnamaldehyde	-	Rattus norvegicus
2-benzyloxycinnamaldehyde	-	Homo sapiens
2-benzyloxycinnamaldehyde	-	Rattus norvegicus
2-hydroxycinnamaldehyde	-	Homo sapiens
2-hydroxycinnamaldehyde	-	Rattus norvegicus
2-pentoxycinnamaldehyde	-	Homo sapiens
2-pentoxycinnamaldehyde	-	Rattus norvegicus
5-fluoro-2-hydroxycinnamaldehyde	-	Escherichia coli
5-fluoro-2-hydroxycinnamaldehyde	-	Homo sapiens
5-fluoro-2-hydroxycinnamaldehyde	-	Rattus norvegicus
additional information	not inhibited by trans-cinnamaldehyde and 2-hydroxycinnamaldehyde after 1 h of incubation	Escherichia coli
additional information	not inhibited by 2-methoxycinnamaldehyde and cinnamic acid	Homo sapiens
additional information	not inhibited by 2-methoxycinnamaldehyde and cinnamic acid after 1 h of incubation	Rattus norvegicus
trans-cinnamaldehyde	-	Homo sapiens
trans-cinnamaldehyde	-	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HCT-116 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5,5'-dithiobis-(2-nitrobenzoic acid) + NADPH + H+	-	Escherichia coli	2-nitro-5-thiobenzoate + NADP+	-	?
5,5'-dithiobis-(2-nitrobenzoic acid) + NADPH + H+	-	Homo sapiens	2-nitro-5-thiobenzoate + NADP+	-	?
5,5'-dithiobis-(2-nitrobenzoic acid) + NADPH + H+	-	Rattus norvegicus	2-nitro-5-thiobenzoate + NADP+	-	?
thioredoxin disulfide + NADPH + H+	-	Escherichia coli	?	-	?
thioredoxin disulfide + NADPH + H+	-	Homo sapiens	?	-	?
thioredoxin disulfide + NADPH + H+	-	Rattus norvegicus	?	-	?

Synonyms

Synonyms	Comment	Organism
thioredoxin reductase	-	Escherichia coli
thioredoxin reductase	-	Homo sapiens
thioredoxin reductase	-	Rattus norvegicus
TrxR	-	Escherichia coli
TrxR	-	Homo sapiens
TrxR	-	Rattus norvegicus

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Escherichia coli
NADPH	-	Homo sapiens
NADPH	-	Rattus norvegicus

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.007	-	1 h incubation with recombinant TrxR, in TE buffer, at 25°C	Rattus norvegicus	5-fluoro-2-hydroxycinnamaldehyde
0.017	-	1 h incubation with recombinant TrxR, in TE buffer, at 25°C	Rattus norvegicus	2-benzoyloxycinnamaldehyde
0.0253	-	1 h incubation with recombinant TrxR, in TE buffer, at 25°C	Rattus norvegicus	2-hydroxycinnamaldehyde
0.0636	-	1 h incubation with recombinant TrxR, in TE buffer, at 25°C	Rattus norvegicus	2-benzyloxycinnamaldehyde
0.0713	-	1 h incubation with recombinant TrxR, in TE buffer, at 25°C	Rattus norvegicus	trans-cinnamaldehyde
0.0844	-	1 h incubation with recombinant TrxR, in TE buffer, at 25°C	Escherichia coli	5-fluoro-2-hydroxycinnamaldehyde
0.0994	-	1 h incubation with recombinant TrxR, in TE buffer, at 25°C	Escherichia coli	2-benzoyloxycinnamaldehyde
0.1	-	1 h incubation with recombinant TrxR, in TE buffer, at 25°C	Rattus norvegicus	2-pentoxycinnamaldehyde

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Release 2023.1 (January 2023)