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Literature summary for 1.8.1.9 extracted from
- Activation of transcription initiation by Spx: formation of transcription complex and identification of a Cis-acting element required for transcriptional activation (2008), Mol. Microbiol., 69, 765-779.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Hg2+ | potently inhibits (at concentrations of 5-50 nM) TrxR1 activity in both cell-free and intracellular assays | Homo sapiens |  |
| Hg2+ | - |
Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q16881 | - |
- |
| Rattus norvegicus | O89049 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| THP-1 cell | Hg(II) potently inhibits (at concentrations of 5-50 nM) TrxR1 activity in both cell-free and intracellular assays | Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| thioredoxin disulfide + NADPH + H+ | - |
Homo sapiens | thioredoxin + NADP+ | - |
? | |
| thioredoxin disulfide + NADPH + H+ | - |
Rattus norvegicus | thioredoxin + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| thioredoxin reductase-1 | - |
Homo sapiens |
| thioredoxin reductase-1 | - |
Rattus norvegicus |
| Trx1 | - |
Homo sapiens |
| Trx1 | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Homo sapiens | |
| NADPH | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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