Literature summary for 1.8.1.9 extracted from

Cheng, Z.; Arscott, L.D.; Ballou, D.P.; Williams, C.H.
The relationship of the redox potentials of thioredoxin and thioredoxin reductase from Drosophila melanogaster to the enzymatic mechanism: reduced thioredoxin is the reductant of glutathione in Drosophila (2007), Biochemistry, 46, 7875-7885.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
thioredoxin disulfide + NADPH + H+	Drosophila melanogaster	DmTrxR catalyzes the reversible transfer of reducing equivalents from NADPH to DmTrx-2. This process is consistent with the corresponding redox potentials and is essential for GSSG/GSH cycling in Drosophila melanogaster, which is deficient in glutathione reductase	thioredoxin + NADP+	-	r

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
thioredoxin disulfide + NADPH + H+	DmTrxR catalyzes the reversible transfer of reducing equivalents from NADPH to DmTrx-2. This process is consistent with the corresponding redox potentials and is essential for GSSG/GSH cycling in Drosophila melanogaster, which is deficient in glutathione reductase	Drosophila melanogaster	thioredoxin + NADP+	-	r
thioredoxin disulfide + NADPH + H+	DmTrxR catalyzes the reversible transfer of reducing equivalents from NADPH to DmTrx-2	Drosophila melanogaster	thioredoxin + NADP+	-	r

Synonyms

Synonyms	Comment	Organism
DmTrxR	-	Drosophila melanogaster

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Drosophila melanogaster

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Release 2023.1 (January 2023)