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Literature summary for 1.8.1.9 extracted from

  • Fang, J.; Lu, J.; Holmgren, A.
    Thioredoxin reductase is irreversibly modified by curcumin: a novel molecular mechanism for its anticancer activity (2005), J. Biol. Chem., 280, 25284-25290.
    View publication on PubMed
Search for more literature for 1.8.1.9

Inhibitors

Inhibitors Comment Organism Structure
trans,trans-curcumin 0.01-0.05 mM, IC50: 0.0015 mM, irreversible inhibition Homo sapiens
trans,trans-curcumin IC50: 0.0036 mM, irreversible inhibition after incubation at room temperature for 2 h in vitro Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol TrxR1 Homo sapiens 5829
-
cytosol TrxR1 Rattus norvegicus 5829
-
mitochondrion TrxR2 Homo sapiens 5739
-
mitochondrion TrxR2 Rattus norvegicus 5739
-
nucleus TrxR1 Homo sapiens 5634
-
nucleus TrxR1 Rattus norvegicus 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
thioredoxin + NADP+
-
 Homo sapiens thioredoxin disulfide + NADPH
-
 ?
thioredoxin + NADP+
-
 Rattus norvegicus thioredoxin disulfide + NADPH
-
 ?

Synonyms

Synonyms Comment Organism
thioredoxin reductase
-
 Homo sapiens
thioredoxin reductase
-
 Rattus norvegicus
TrxR
-
 Homo sapiens
TrxR
-
 Rattus norvegicus
TrxR1
-
 Homo sapiens
TrxR1
-
 Rattus norvegicus
TrxR2
-
 Homo sapiens
TrxR2
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0015
-
 0.01-0.05 mM, IC50: 0.0015 mM, irreversible inhibition Homo sapiens trans,trans-curcumin
0.0036
-
 IC50: 0.0036 mM, irreversible inhibition after incubation at room temperature for 2 h in vitro Rattus norvegicus trans,trans-curcumin