Inhibitors | Comment | Organism | Structure |
---|---|---|---|
gadopentetic acid | non-competitive inhibition | Homo sapiens | |
ketotifen | non-competitive inhibition | Homo sapiens | |
meloxicam | non-competitive inhibition | Homo sapiens | |
phenyramidol | competitive inhibition | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione disulfide + NADPH + H+ | Homo sapiens | - |
glutathione + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
ammonium sulfate precipitation, 2,5-ADP Sepharose 4B affinity column chromatography, and Sephadex G-200 gel filtration | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
1.5 | - |
enzyme from hemolysate, at pH 8.0 and 25°C | Homo sapiens |
314 | - |
after 209fold purification, at pH 8.0 and 25°C | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
glutathione disulfide + NADPH + H+ | - |
Homo sapiens | glutathione + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glutathione:NADP+ oxidoreductase | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0008 | - |
ketotifen | in 40 mM Tris-HCl buffer, pH 8.0, at 25°C | Homo sapiens | |
0.0061 | - |
meloxicam | in 40 mM Tris-HCl buffer, pH 8.0, at 25°C | Homo sapiens | |
0.434 | - |
phenyramidol | in 40 mM Tris-HCl buffer, pH 8.0, at 25°C | Homo sapiens | |
28.84 | - |
gadopentetic acid | in 40 mM Tris-HCl buffer, pH 8.0, at 25°C | Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.012 | - |
in 40 mM Tris-HCl buffer, pH 8.0, at 25°C | Homo sapiens | ketotifen | |
0.029 | - |
in 40 mM Tris-HCl buffer, pH 8.0, at 25°C | Homo sapiens | meloxicam | |
0.99 | - |
in 40 mM Tris-HCl buffer, pH 8.0, at 25°C | Homo sapiens | phenyramidol | |
138 | - |
in 40 mM Tris-HCl buffer, pH 8.0, at 25°C | Homo sapiens | gadopentetic acid |