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Literature summary for 1.8.1.7 extracted from

  • Zhao, Y.; Seefeldt, T.; Chen, W.; Carlson, L.; Stoebner, A.; Hanson, S.; Foll, R.; Matthees, D.P.; Palakurthi, S.; Guan, X.
    Increase in thiol oxidative stress via glutathione reductase inhibition as a novel approach to enhance cancer sensitivity to X-ray irradiation (2009), Free Radic. Biol. Med., 47, 176-183.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
2-acetylamino-3-[4-(2-acetylamino-2-carboxyethylsulfanylthiocarbonylamino)phenylthiocarbamoylsulfanyl]propionic acid irreversible glutathione reductase inhibitor Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-431 cell
-
Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-
NCI-H226 cell
-
Homo sapiens
-
OVCAR-3 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione disulfide + NADPH + H+
-
Homo sapiens glutathione + NADP+
-
?

Synonyms

Synonyms Comment Organism
glutathione reductase
-
Homo sapiens

Cofactor

Cofactor Comment Organism Structure
FAD
-
Homo sapiens
NADPH
-
Homo sapiens

General Information

General Information Comment Organism
malfunction glutathione reductase inhibition significantly enhances cancer sensitivity to X-ray irradiation through glutathione disulfide increase Homo sapiens