Literature summary for 1.8.1.7 extracted from

Li, S.; Zhang, J.; Li, J.; Chen, D.; Matteucci, M.; Curd, J.; Duan, J.X.
Inhibition of both thioredoxin reductase and glutathione reductase may contribute to the anticancer mechanism of TH-302 (2010), Biol. Trace Elem. Res., 136, 294-301.

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Inhibitors

Inhibitors	Comment	Organism	Structure
TH-302	TH-302 at 300 mg/kg significantly inhibits glutathione reductase activity by 60% as compared with the controls, at 3 h after the injection	Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
glutathione disulfide + NADPH + H+	Mus musculus	-	glutathione + NADP+	-	?

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
glutathione disulfide + NADPH + H+	-	Mus musculus	glutathione + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
glutathione reductase	-	Mus musculus

Cofactor

Cofactor	Comment	Organism	Structure
FAD	-	Mus musculus
NADPH	-	Mus musculus

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Release 2023.1 (January 2023)