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Literature summary for 1.8.1.7 extracted from

  • Bishop, G.M.; Dringen, R.; Robinson, S.R.
    Zinc stimulates the production of toxic reactive oxygen species (ROS) and inhibits glutathione reductase in astrocytes (2007), Free Radic. Biol. Med., 42, 1222-1230.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
carmustine
-
Rattus norvegicus
Zn2+ Zn acetate at concentrations of 0.1 mM or greater inactivate glutathione reductase via an NADPH-dependent mechanism. Zn2+ is a highly effective inhibitor of glutathione reductase activity in astrocytes. This inhibition impairs their capacity to detoxify H2O2 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
Wistar
-
Rattus norvegicus Wistar
-
Wistar
-

Source Tissue

Source Tissue Comment Organism Textmining
astrocyte
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GSSG + NADPH + H+
-
Rattus norvegicus glutathione + NADP+
-
?
GSSG + NADPH + H+
-
Rattus norvegicus Wistar glutathione + NADP+
-
?

Synonyms

Synonyms Comment Organism
glutathione reductase
-
Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Rattus norvegicus