Inhibitors | Comment | Organism | Structure |
---|---|---|---|
carmustine | - |
Rattus norvegicus | |
Zn2+ | Zn acetate at concentrations of 0.1 mM or greater inactivate glutathione reductase via an NADPH-dependent mechanism. Zn2+ is a highly effective inhibitor of glutathione reductase activity in astrocytes. This inhibition impairs their capacity to detoxify H2O2 | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
Wistar | - |
Rattus norvegicus Wistar | - |
Wistar | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
astrocyte | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GSSG + NADPH + H+ | - |
Rattus norvegicus | glutathione + NADP+ | - |
? | |
GSSG + NADPH + H+ | - |
Rattus norvegicus Wistar | glutathione + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glutathione reductase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Rattus norvegicus |