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Literature summary for 1.8.1.7 extracted from

  • Hu, Y.; Urig, S.; Koncarevic, S.; Wu, X.; Fischer, M.; Rahlfs, S.; Mersch-Sundermann, V.; Becker, K.
    Glutathione- and thioredoxin-related enzymes are modulated by sulfur-containing chemopreventive agents (2007), Biol. Chem., 388, 1069-1081.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
allyl isothiocyanate
-
Homo sapiens
Benzyl isothiocyanate
-
Homo sapiens
phenethyl isothiocyanate
-
Homo sapiens
sulforaphane
-
Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P00390
-
-

Source Tissue

Source Tissue Comment Organism Textmining
placenta
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GSSG + NADPH + H+
-
Homo sapiens glutathione + NADP+
-
?

Synonyms

Synonyms Comment Organism
glutathione reductase
-
Homo sapiens
GR
-
Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.029
-
25°C, 30 min preincubation Homo sapiens Benzyl isothiocyanate
0.045
-
25°C, 30 min preincubation Homo sapiens sulforaphane
0.05
-
25°C, 30 min preincubation Homo sapiens phenethyl isothiocyanate
0.1
-
25°C, 30 min preincubation Homo sapiens allyl isothiocyanate