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Literature summary for 1.8.1.7 extracted from

  • Nagaoka, Y.; Iuchi, Y.; Ikeda, Y.; Fujii, J.
    Glutathione reductase is expressed at high levels in pancreatic islet cells (2004), Redox Rep., 9, 321-324.
    View publication on PubMed
Search for more literature for 1.8.1.7

Inhibitors

Inhibitors Comment Organism Structure
1,3-bis-(2-chloroethyl) 1-nitrosourea irreversible inhibition Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glutathione disulfide + NADPH Rattus norvegicus antioxidant enzyme, protects the pancreatic cell against reactive oxygen species involved in the diabetogenic agent-induced dysfunction of pancreatic-beta-cells glutathione + NADP+
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 7-week-old Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
pancreas localization of the enzyme in pancreatic tissue, overview Rattus norvegicus
-
pancreatic acinar cell pancreas, lower expression level than in islet cells Rattus norvegicus
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pancreatic islet high expression level Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione disulfide + NADPH
-
 Rattus norvegicus glutathione + NADP+
-
 ?
glutathione disulfide + NADPH antioxidant enzyme, protects the pancreatic cell against reactive oxygen species involved in the diabetogenic agent-induced dysfunction of pancreatic-beta-cells Rattus norvegicus glutathione + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
glutathione reductase
-
 Rattus norvegicus
GR
-
 Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Rattus norvegicus