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Literature summary for 1.8.1.7 extracted from

  • Su, D.; Novoselov, S.V.; Sun, Q.A.; Moustafa, M.E.; Zhou, Y.; Oko, R.; Hatfield, D.L.; Gladyshev, V.N.
    Mammalian selenoprotein thioredoxin/glutathione reductase: roles in disulfide bond formation and sperm maturation (2005), J. Biol. Chem., 280, 26491-26498.
    View publication on PubMed
Search for more literature for 1.8.1.7

Cloned(Commentary)

Cloned (Comment) Organism
tissue expression analysis Mus musculus

Metals/Ions

Metals/Ions Comment Organism Structure
selenium regulates the enzyme expression pattern, enzyme contains a catalytic selenocysteine Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glutathione disulfide + NADPH Mus musculus
-
 glutathione + NADP+
-
 ?
glutathione disulfide + NADPH Rattus norvegicus
-
 glutathione + NADP+
-
 ?
additional information Rattus norvegicus enzyme forms a disulfide bond formation system together with glutathione peroxidase GPx4 ?
-
 ?
additional information Mus musculus enzyme forms a disulfide bond formation system together with glutathione peroxidase GPx4, selenium regulates the enzyme expression pattern ?
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 enzyme is a bifunctional selenoprotein
-
Rattus norvegicus
-
 enzyme is a bifunctional selenoprotein
-

Reaction

Reaction Comment Organism Reaction ID
2 glutathione + NADP+ = glutathione disulfide + NADPH + H+ enzyme contains a catalytic selenocysteine Rattus norvegicus
a

Source Tissue

Source Tissue Comment Organism Textmining
heart expression only before puberty Mus musculus
-
liver expression only before puberty Mus musculus
-
lung expression only before puberty Mus musculus
-
additional information tissue expression analysis Mus musculus
-
spermatid at the site of mitochondrial sheath formation in elongating spermatids, absent in mature sperm Mus musculus
-
spermatid at the site of mitochondrial sheath formation in elongating spermatids, absent in mature sperm Rattus norvegicus
-
testis accumulation after puberty Mus musculus
-
testis accumulation after puberty Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glutathione disulfide + NADPH
-
 Mus musculus glutathione + NADP+
-
 ?
glutathione disulfide + NADPH
-
 Rattus norvegicus glutathione + NADP+
-
 ?
additional information enzyme forms a disulfide bond formation system together with glutathione peroxidase GPx4 Rattus norvegicus ?
-
 ?
additional information enzyme forms a disulfide bond formation system together with glutathione peroxidase GPx4, selenium regulates the enzyme expression pattern Mus musculus ?
-
 ?
additional information enzyme can catalyze isomerization of protein and interprotein disulfide bonds, the function is localized in the thiol domain Mus musculus ?
-
 ?
additional information enzyme can catalyze isomerization of protein and interprotein disulfide bonds, the function is localized in the thiol domain Rattus norvegicus ?
-
 ?

Subunits

Subunits Comment Organism
More enzyme is a fusion protein consisting of an N-terminal glutaredoxin domain and the thioredoxin reductase module Mus musculus
More enzyme is a fusion protein consisting of an N-terminal glutaredoxin domain and the thioredoxin reductase module Rattus norvegicus

Synonyms

Synonyms Comment Organism
thioredoxin/glutathione reductase
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Mus musculus
NADPH
-
 Rattus norvegicus