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Literature summary for 1.8.1.7 extracted from
- Human erythrocyte glutathione reductase. I. Purification and properties (1976), Biochim. Biophys. Acta, 445, 309-323.
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| NADH-X | - |
Homo sapiens |  |
| NADP+ | - |
Homo sapiens | |
| NADPH | derivatives | Homo sapiens | |
| NADPH-X | - |
Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.009 | - |
NADPH | pH 6.8 | Homo sapiens | |
| 0.25 | - |
NADH | pH 6.05 | Homo sapiens | |
| 0.67 | - |
NADH | pH 6.8 | Homo sapiens | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 34 | - |
purified enzyme, with NADH | Homo sapiens |
| 207 | - |
purified protein, with NADPH | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione disulfide + NADH + H+ | - |
Homo sapiens | glutathione + NAD+ | - |
? | |
| GSSG + NADPH | - |
Homo sapiens | glutathione + NADP+ | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | - |
NADH + GSSG | Homo sapiens |
| 6.8 | - |
NADPH + GSSG | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | FAD enzyme | Homo sapiens | |
| NADH | a single enzyme uses both NADPH and NADH as hydrogen donors | Homo sapiens | |
| NADPH | a single enzyme uses both NADPH and NADH as hydrogen donors | Homo sapiens | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0072 | - |
NADP+ | with NADH at pH 6.8 | Homo sapiens | |
| 0.018 | - |
NADP+ | with NADH at pH 6.05 | Homo sapiens | |
| 0.022 | - |
NADPH-X | derivative, pH 6.8, with NADPH | Homo sapiens | |
| 0.055 | - |
NADP+ | with NADPH at pH 6.8 | Homo sapiens | |
| 0.54 | - |
NADH-X | derivative, pH 6.8, with NADH | Homo sapiens | |
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