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Literature summary for 1.8.1.7 extracted from
- Glutathione reductase from human erythrocytes. Catalytic properties and aggregation (1976), Eur. J. Biochem., 67, 231-238.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| KCl | - |
Homo sapiens |  |
| Sodium phosphate | - |
Homo sapiens | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| glutathione | - |
Homo sapiens | |
| NADH | - |
Homo sapiens | |
| NADP+ | competitive against NADPH | Homo sapiens | |
| NADPH | promotes formation of aggregates, reversible by thiols, e.g. glutathione or 2-mercaptoethanol | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.008 | - |
NADPH | - |
Homo sapiens | |
| 0.065 | - |
GSSG | - |
Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 100000 | - |
- |
Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Oxidation Stability
| Oxidation Stability | Organism |
|---|---|
| oxygen promotes enzyme aggregation by oxidation of thiols, that prevent oxidation of the enzyme | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 250 | - |
purified enzyme | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GSSG + NADPH | - |
Homo sapiens | glutathione + NADP+ | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Homo sapiens |
| More | NADH promotes aggregation | Homo sapiens |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 210 | - |
GSSG | - |
Homo sapiens | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 5.7 | - |
NADH + GSSG | Homo sapiens |
| 6.8 | - |
NADPH + GSSG | Homo sapiens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADH | - |
Homo sapiens | |
| NADPH | NADPH promoted aggregation of the enzyme | Homo sapiens | |
| NADPH | best electron donor | Homo sapiens | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.07 | - |
NADP+ | - |
Homo sapiens | |
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