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Literature summary for 1.8.1.4 extracted from
- Conformational change near the redox center of dihydrolipoamide dehydrogenase induced by NAD+ to regulate the enzyme activity (2015), J. Fluoresc., 25, 577-583 .
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| X-ray diffraction structure determination and analysis | Geobacillus stearothermophilus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dihydrolipoamide + NAD+ | Geobacillus stearothermophilus | - |
lipoamide + NADH + H+ | - |
r |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Geobacillus stearothermophilus | P11959 | i.e. Geobacillus stearothermophilus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dihydrolipoamide + NAD+ | - |
Geobacillus stearothermophilus | lipoamide + NADH + H+ | - |
r | |
| dihydrolipoamide + NAD+ | dihydrolipoamide dehydrogenase (LipDH) transfers two electrons from dihydrolipoamide to NAD+ mediated by FAD | Geobacillus stearothermophilus | lipoamide + NADH + H+ | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Geobacillus stearothermophilus |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| dihydrolipoamide dehydrogenase | - |
Geobacillus stearothermophilus |
| LipDH | - |
Geobacillus stearothermophilus |
| pdhD | - |
Geobacillus stearothermophilus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FAD | a single FAD is non-covalently arranged in each subunit | Geobacillus stearothermophilus | |
| NAD+ | - |
Geobacillus stearothermophilus | |
| NADH | - |
Geobacillus stearothermophilus | |
General Information
| General Information | Comment | Organism |
|---|---|---|
| additional information | conformational change near the redox center of dihydrolipoamide dehydrogenase induced by NAD+ to regulate the enzyme activity | Geobacillus stearothermophilus |
| physiological function | dihydrolipoamide dehydrogenase (LipDH) transfers two electrons from dihydrolipoamide to NAD+ mediated by FAD. Since this reaction is the final step of a series of catalytic reaction of pyruvate dehydrogenase multi-enzyme complex (PDC), LipDH is a key enzyme to maintain the fluent metabolic flow | Geobacillus stearothermophilus |
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Release 2023.1 (January 2023)
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