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Literature summary for 1.8.1.4 extracted from

  • Dhanasekaran, M.; Albano, C.B.; Pellet, L.; Karuppagounder, S.S.; Uthayathas, S.; Suppiramaniam, V.; Brown-Borg, H.; Ebadi, M.
    Role of lipoamide dehydrogenase and metallothionein on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced neurotoxicity (2008), Neurochem. Res., 33, 980-984.
    View publication on PubMed
Search for more literature for 1.8.1.4

Activating Compound

Activating Compound Comment Organism Structure
Zn2+ dose dependently enhances the lipoamide dehydrogenase activity Mus musculus

Application

Application Comment Organism
medicine lipoamide dehydrogenase activity and metallothionein levels may be critical for dopaminergic neuronal survival in Parkinson's disease. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine can affect the lipoamide dehydrogenase activity and metallothionein content to exert its neurotoxicity Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine at higher concentrations (2 mM) significantly inhibits the lipoamide dehydrogenase activity Mus musculus
1-methyl-4-phenylpyridinium at lower concentrations (1 mM) as compared to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine significantly inhibits the lipoamide dehydrogenase activity Mus musculus
Fe2+ at high concentrations has significant inhibitory effect on the lipoamide dehydrogenase activity Mus musculus
additional information calcium and copper do not affect the enzyme activity Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57/Bl-6 mice
-
Mus musculus C57/Bl-6
-
 C57/Bl-6 mice
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
coenzyme Q-10 + NADPH
-
 Mus musculus ubiquinol + NADP+
-
 ?
coenzyme Q-10 + NADPH
-
 Mus musculus C57/Bl-6 ubiquinol + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
lipoamide dehydrogenase
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Mus musculus