Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activity of DLDH diaphorase is both protein amount- and time-dependent | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
analysis | development of a blue native-PAGE-based method for isolation of enzymatically active DLDH from animal tissues and visualization as well as quantification of its diaphorase activity using the NADH/nitroblue tetrazolium detection system | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Angeli's salt | at 2 mM, induces a 90% loss in DLDH diaphorase activity | Rattus norvegicus | |
Diethylamine NONOate | induces 71% loss in diaphorase activity at 10 mM, but does not induce any activity loss at 2 mM | Rattus norvegicus | |
additional information | diamide, GSH, GSSG, cysteine and nitrite do not exhibit any inhibitory effects | Rattus norvegicus | |
N-ethylmaleimide | induces more than 95% loss in DLDH diaphorase activity | Rattus norvegicus | |
S-nitrosocysteine | induces a 62% loss in diaphorase activity at 2 mM and an 88% loss at 10 mM | Rattus norvegicus | |
S-nitrosoglutathione | induces 84% loss in diaphorase activity at 10 mM, but does not induce any activity loss at 2 mM | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | DLDH exclusively exists in mitochondria | Rattus norvegicus | 5739 | - |
additional information | no DLDH diaphorase activity in the cytosol | Rattus norvegicus | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
adult Sprague-Dawley rats | - |
Purification (Comment) | Organism |
---|---|
gel filtration | Rattus norvegicus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Rattus norvegicus | - |
heart | - |
Rattus norvegicus | - |
kidney | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
lung | - |
Rattus norvegicus | - |
skeletal muscle | - |
Rattus norvegicus | - |
testis | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
nitro blue tetrazolium + NADH | - |
Rattus norvegicus | ? + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dihydrolipoamide dehydrogenase | - |
Rattus norvegicus |
DLDH | - |
Rattus norvegicus |
DLDH dehydrogenase | - |
Rattus norvegicus |
DLDH diaphorase | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
additional information | no activity with NADPH | Rattus norvegicus | |
NADH | - |
Rattus norvegicus |