Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
acrosome | associated to the matrix, release of enzyme during acrosomal exocytosis | Mesocricetus auratus | - |
- |
Golgi apparatus | juxtanuclear localization, like Golgi, in spermatids | Mesocricetus auratus | 5794 | - |
mitochondrion | in spermatocytes | Mesocricetus auratus | 5739 | - |
additional information | release of enzyme during acrosomal exocytosis, extramitochondrial localization in epididymal spermatozoa in mammalia | Mesocricetus auratus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dihydrolipoamide + NAD+ | Mesocricetus auratus | regulation of activity dependent on tyrosine-phosphorylation of the enzyme | lipoamide + NADH | - |
r | |
additional information | Mesocricetus auratus | the enzyme is required for hyperactivation, i.e. enhanced motility, and acrosome reaction of hamster spermatozoa, the post-pyruvate metabolic enzyme shows dual involvement and regulation during sperm capacitation, control of the directionality of enzyme activity during sperm capacitation | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mesocricetus auratus | - |
male | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
phosphoprotein | tyrosine-phosphorylated differently concerning time course in the principal piece of the flagella and the acrosome in capacitated spermatozoa, tyrosine-phosphorylation has regulatory function | Mesocricetus auratus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
sperm flagellum | - |
Mesocricetus auratus | - |
spermatid | - |
Mesocricetus auratus | - |
spermatocyte | - |
Mesocricetus auratus | - |
spermatozoon | - |
Mesocricetus auratus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Mesocricetus auratus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
dihydrolipoamide + NAD+ | - |
Mesocricetus auratus | lipoamide + NADH | - |
r | |
dihydrolipoamide + NAD+ | regulation of activity dependent on tyrosine-phosphorylation of the enzyme | Mesocricetus auratus | lipoamide + NADH | - |
r | |
additional information | the enzyme is required for hyperactivation, i.e. enhanced motility, and acrosome reaction of hamster spermatozoa, the post-pyruvate metabolic enzyme shows dual involvement and regulation during sperm capacitation, control of the directionality of enzyme activity during sperm capacitation | Mesocricetus auratus | ? | - |
? | |
NADH + H+ + oxidized 2,6-dichlorophenolindophenol | - |
Mesocricetus auratus | NAD+ + reduced 2,6-dichlorophenolindophenol | - |
? | |
O2 + NADH | - |
Mesocricetus auratus | H2O2 + NAD+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dihydrolipoamide dehydrogenase | - |
Mesocricetus auratus |
E3 | - |
Mesocricetus auratus |
More | the enzyme is the E3 component of the pyruvate dehydrogenase multienzyme complex | Mesocricetus auratus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NAD+ | - |
Mesocricetus auratus | |
NADH | - |
Mesocricetus auratus |