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Literature summary for 1.8.1.4 extracted from

  • Mitra, K.; Rangaraj, N.; Shivaji, S.
    Novelty of the pyruvate metabolic enzyme dihydrolipoamide dehydrogenase in spermatozoa: Correlation of its localization, tyrosine phosphorylation and activity during sperm capacitation (2005), J. Biol. Chem., 280, 25743-25753.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
acrosome associated to the matrix, release of enzyme during acrosomal exocytosis Mesocricetus auratus
-
-
Golgi apparatus juxtanuclear localization, like Golgi, in spermatids Mesocricetus auratus 5794
-
mitochondrion in spermatocytes Mesocricetus auratus 5739
-
additional information release of enzyme during acrosomal exocytosis, extramitochondrial localization in epididymal spermatozoa in mammalia Mesocricetus auratus
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dihydrolipoamide + NAD+ Mesocricetus auratus regulation of activity dependent on tyrosine-phosphorylation of the enzyme lipoamide + NADH
-
r
additional information Mesocricetus auratus the enzyme is required for hyperactivation, i.e. enhanced motility, and acrosome reaction of hamster spermatozoa, the post-pyruvate metabolic enzyme shows dual involvement and regulation during sperm capacitation, control of the directionality of enzyme activity during sperm capacitation ?
-
?

Organism

Organism UniProt Comment Textmining
Mesocricetus auratus
-
male
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein tyrosine-phosphorylated differently concerning time course in the principal piece of the flagella and the acrosome in capacitated spermatozoa, tyrosine-phosphorylation has regulatory function Mesocricetus auratus

Source Tissue

Source Tissue Comment Organism Textmining
sperm flagellum
-
Mesocricetus auratus
-
spermatid
-
Mesocricetus auratus
-
spermatocyte
-
Mesocricetus auratus
-
spermatozoon
-
Mesocricetus auratus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Mesocricetus auratus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dihydrolipoamide + NAD+
-
Mesocricetus auratus lipoamide + NADH
-
r
dihydrolipoamide + NAD+ regulation of activity dependent on tyrosine-phosphorylation of the enzyme Mesocricetus auratus lipoamide + NADH
-
r
additional information the enzyme is required for hyperactivation, i.e. enhanced motility, and acrosome reaction of hamster spermatozoa, the post-pyruvate metabolic enzyme shows dual involvement and regulation during sperm capacitation, control of the directionality of enzyme activity during sperm capacitation Mesocricetus auratus ?
-
?
NADH + H+ + oxidized 2,6-dichlorophenolindophenol
-
Mesocricetus auratus NAD+ + reduced 2,6-dichlorophenolindophenol
-
?
O2 + NADH
-
Mesocricetus auratus H2O2 + NAD+
-
?

Synonyms

Synonyms Comment Organism
dihydrolipoamide dehydrogenase
-
Mesocricetus auratus
E3
-
Mesocricetus auratus
More the enzyme is the E3 component of the pyruvate dehydrogenase multienzyme complex Mesocricetus auratus

Cofactor

Cofactor Comment Organism Structure
NAD+
-
Mesocricetus auratus
NADH
-
Mesocricetus auratus