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Literature summary for 1.8.1.4 extracted from

  • Nordman, T.; Xia, L.; Bjorkhem-Bergman, L.; Damdimopoulos, A.; Nalvarte, I.; Arner, E.S.; Spyrou, G.; Eriksson, L.C.; Bjornstedt, M.; Olsson, J.M.
    Regeneration of the antioxidant ubiquinol by lipoamide dehydrogenase, thioredoxin reductase and glutathione reductase (2003), Biofactors, 18, 45-50.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Sus scrofa 5829
-
microsome
-
Sus scrofa
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ highly stimulating for ubiquinone reduction Sus scrofa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
55000
-
2 * 55000, about, SDS-PAGE Sus scrofa
115000
-
gel filtration Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ubiquinone + NAD(P)H Sus scrofa enzyme is involved in extramitochondrial regeneration of the important antioxidant ubiquinol required for cell protection against peroxidation ubiquinol + NAD(P)+
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
Sus scrofa
-
heart
-
Sus scrofa
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ubiquinone + NAD(P)H
-
Sus scrofa ubiquinol + NAD(P)+
-
?
ubiquinone + NAD(P)H enzyme is involved in extramitochondrial regeneration of the important antioxidant ubiquinol required for cell protection against peroxidation Sus scrofa ubiquinol + NAD(P)+
-
?

Subunits

Subunits Comment Organism
dimer 2 * 55000, about, SDS-PAGE Sus scrofa

Synonyms

Synonyms Comment Organism
DT-diaphorase
-
Sus scrofa
LipDH
-
Sus scrofa
lipoamide dehydrogenase
-
Sus scrofa

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
additional information
-
highest activity at acidic pH Sus scrofa

Cofactor

Cofactor Comment Organism Structure
FAD flavoenzyme, 1 FAD per enzyme subunit, functionally important Sus scrofa
additional information enzyme contains 1 disulfide/dithiol per subunit Sus scrofa
NAD(P)H NADPH and NADH are equally effective as cofactors Sus scrofa