Literature summary for 1.8.1.12 extracted from

Chacon-Vargas, K.F.; Nogueda-Torres, B.; Sanchez-Torres, L.E.; Suarez-Contreras, E.; Villalobos-Rocha, J.C.; Torres-Martinez, Y.; Lara-Ramirez, E.E.; Fiorani, G.; Krauth-Siegel, R.L.; Bolognesi, M.L.; Monge, A.; Rivera, G.
Trypanocidal activity of quinoxaline 1,4 di-N-oxide derivatives as trypanothione reductase inhibitors (2017), Molecules, 22, 220 .

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Crystallization (Commentary)

Crystallization (Comment)	Organism
molecular docking of inhibitor isopropyl 2-isobutyryl-3-trifluoromethylquinoxaline-7-carboxylate 1,4-di-N-oxide	Trypanosoma cruzi

Inhibitors

Inhibitors	Comment	Organism	Structure
isopropyl 2-isobutyryl-3-trifluoromethylquinoxaline-7-carboxylate 1,4-di-N-oxide	noncompetitive. IC50 values against strains NINOA and INC-5 are 0.060 microM and 0.073 microM, respectively, IC50 against human glutathione reductase is 0.050 microM	Trypanosoma cruzi

Organism

Organism	UniProt	Comment	Textmining
Trypanosoma cruzi	P28593	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
trypanothione disulfide + NADPH + H+	-	Trypanosoma cruzi	trypanothione + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
TPR	-	Trypanosoma cruzi

Cofactor

Cofactor	Comment	Organism	Structure
NADPH	-	Trypanosoma cruzi

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Release 2023.1 (January 2023)