Cloned (Comment) | Organism |
---|---|
- |
Leishmania infantum |
Crystallization (Comment) | Organism |
---|---|
in complex with inhibitor 6-(sec-butoxy)-2-((3-chlorophenyl)thio)pyrimidin-4-amine. The inhibitor binds to the catalytic site and interacts with residues Glu466', Cys57 and Cys52 | Leishmania infantum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-(sec-butoxy)-2-((3-chlorophenyl)thio)pyrimidin-4-amine | i.e. RD 777. IC50 value 0.029 microM for promastigote assay. Competitive with respect to substrate trypanothione disulfide | Leishmania infantum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Leishmania infantum | A4HSF7 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
TryR | - |
Leishmania infantum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00025 | - |
6-(sec-butoxy)-2-((3-chlorophenyl)thio)pyrimidin-4-amine | pH not specified in the publication, temperature not specified in the publication | Leishmania infantum |