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Literature summary for 1.8.1.12 extracted from

  • da Rocha Pita, S.S.; Cirino, J.J.; de Alencastro, R.B.; Castro, H.C.; Rodrigues, C.R.; Albuquerque, M.G.
    Molecular docking of a series of peptidomimetics in the trypanothione binding site of T. cruzi trypanothione reductase (2009), J. Mol. Graph. Model., 28, 330-335.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
benzoyl-Gly-L-Arg-L-Arg-L-Leu-beta-naphthylamide reversible and competitive inhibition Trypanosoma cruzi
benzoyl-L-Arg-p-nitroanilide reversible and competitive inhibition Trypanosoma cruzi
benzoyl-L-Leu-L-Arg-L-Arg-beta-naphthylamide reversible and competitive inhibition Trypanosoma cruzi
benzoyl-L-Phe-L-Val-L-Arg-7-amido-4-methylcoumarin reversible and competitive inhibition Trypanosoma cruzi
benzoyl-Lys-Phe-Arg-p-nitroanilide reversible and competitive inhibition Trypanosoma cruzi
benzyloxycarbonyl-Ala-Arg-Arg-4-methoxy-beta-naphthylamide reversible and competitive inhibition Trypanosoma cruzi
benzyloxycarbonyl-Gly-Gly-L-Arg-7-amido-4-methylcoumarin reversible and competitive inhibition Trypanosoma cruzi
benzyloxycarbonyl-L-Arg-L-Arg-4-methoxy-beta-naphthylamide reversible and competitive inhibition Trypanosoma cruzi
benzyloxycarbonyl-L-Arg-L-Arg-p-nitroanilide reversible and competitive inhibition Trypanosoma cruzi
benzyloxycarbonyl-L-Arg-p-nitroanilide reversible and competitive inhibition Trypanosoma cruzi
benzyloxycarbonyl-L-Lys-4-methoxy-beta-naphthylamide reversible and competitive inhibition Trypanosoma cruzi
L-Arg-beta-naphthylamide reversible and competitive inhibition Trypanosoma cruzi
L-His-L-Trp-L-His reversible and competitive inhibition Trypanosoma cruzi
L-His-L-Trp-L-Lys reversible and competitive inhibition Trypanosoma cruzi
L-Phe-L-Arg-L-Trp reversible and competitive inhibition Trypanosoma cruzi
L-Phe-L-Met-L-Arg-L-Phe-NH2 reversible and competitive inhibition Trypanosoma cruzi
L-Phe-L-Pro-L-Arg-4-methoxy-beta-naphthylamide reversible and competitive inhibition Trypanosoma cruzi
L-Trp reversible and competitive inhibition Trypanosoma cruzi
L-Trp-beta-naphthylamide reversible and competitive inhibition Trypanosoma cruzi
tert-butyl-L-Leu-L-Arg-L-Arg-7-amido-4-methylcoumarin reversible and competitive inhibition Trypanosoma cruzi
tert-butyl-L-Leu-L-Lys-L-Arg-7-amido-4-methylcoumarin reversible and competitive inhibition Trypanosoma cruzi

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi P28593
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trypanothione disulfide + NADPH + H+
-
Trypanosoma cruzi trypanothione + NADP+
-
?

Synonyms

Synonyms Comment Organism
trypanothione reductase
-
Trypanosoma cruzi

Cofactor

Cofactor Comment Organism Structure
FAD
-
Trypanosoma cruzi
NADPH
-
Trypanosoma cruzi