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Literature summary for 1.8.1.12 extracted from
- The effects by neuroleptics, antimycotics and antibiotics on disulfide reducing enzymes from the human pathogens Acanthamoeba polyphaga and Naegleria fowleri (2007), Exp. Parasitol., 115, 41-47.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ketoconazole | 18% enhancement of activity | Naegleria fowleri |  |
| metronidazole | 68% enhancement of activity | Naegleria fowleri | |
| Pentamidine | 40% enhancement of activity | Naegleria fowleri | |
| rifampicin | 55% enhancement of activity | Naegleria fowleri | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Amphotericin B | 0.0346 mM, 100% inhibition | Naegleria fowleri | |
| chlorpromazine | 0.0896 mM, 80% inhibition | Naegleria fowleri | |
| Mepacrine | 0.0672 mM, 70% inhibition | Naegleria fowleri | |
| miconazole | 0.064 mM, 100% inhibition | Naegleria fowleri | |
| Trifluoperazine | 0.0655 mM, 92% inhibition | Naegleria fowleri | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Naegleria fowleri | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| trypanothione disulfide + NADPH | - |
Naegleria fowleri | trypanothione + NADP+ | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TR | - |
Naegleria fowleri |
| trypanothione reductase | - |
Naegleria fowleri |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| NADPH | - |
Naegleria fowleri | |
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Release 2023.1 (January 2023)
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