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Literature summary for 1.8.1.12 extracted from

  • Hamilton, C.J.; Saravanamuthu, A.; Poupat, C.; Fairlamb, A.H.; Eggleston, I.M.
    Time-dependent inhibitors of trypanothione reductase: analogues of the spermidine alkaloid lunarine and related natural products (2006), Bioorg. Med. Chem., 14, 2266-2278.
    View publication on PubMed
Search for more literature for 1.8.1.12

Inhibitors

Inhibitors Comment Organism Structure
(+/-)-10,11-dihydrolunarine 0.1 mM Lunaria biennis
cis-3-(1,3-dioxolan-2-yl)-8-bromo-9b-(trans-acrylic acid)-1,2,3,4,4a,9b-hexahydrodibenzofuran 0.1 mM Lunaria biennis
cis-3-oxo-8,9b-bis-(trans-N-(acrylamidospermidyl))-1,2,3,4,4a,9b-hexahydrodibenzofuran IC50: 0.029 mM Lunaria biennis
cis-3-oxo-8,9b-bis-(trans-N3-(dimethylamino)propylacrylamido)-1,2,3,4,4a,9b-hexahydrodibenzofuran 0.1 mM Lunaria biennis
cis-3-oxo-8-trans-(N-acrylamidospermidyl)-9b-trans-ethylacrylyl-1,2,3,4,4a,9b-hexahydrodibenzofuran IC50: 0.056 mM Lunaria biennis
cis-3-oxo-8-trans-(N1-acrylamidospermidyl)-9b-trans-ethylacrylyl-1,2,3,4,4a,9b-hexahydrodibenzofuran
-
 Lunaria biennis
lunarine IC50: 0.065 mM Lunaria biennis
lunarinol 0.1 mM Lunaria biennis
additional information no inhibition by 0.1 mM cis-3-(1,3-dioxolan-2-yl)-8,9b-bis-(trans-ethyl-acrylyl)-1,2,3,4,4a,9b-hexahydrodibenzofuran Lunaria biennis
numismine 0.1 mM Lunaria biennis
tetrahydrolunarine 0.1 mM Lunaria biennis
tetrahydrolunarinol 0.1 mM Lunaria biennis

Organism

Organism UniProt Comment Textmining
Lunaria biennis
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
trypanothione disulfide + NADPH
-
 Lunaria biennis trypanothione + NADP+
-
 ?

Synonyms

Synonyms Comment Organism
EC 1.6.4.8 formerly Lunaria biennis
trypanothione reductase
-
 Lunaria biennis
TryR
-
 Lunaria biennis

Cofactor

Cofactor Comment Organism Structure
NADPH
-
 Lunaria biennis

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.049
-
 cis-3-oxo-8-trans-(N1-acrylamidospermidyl)-9b-trans-ethylacrylyl-1,2,3,4,4a,9b-hexahydrodibenzofuran
-
 Lunaria biennis
0.059
-
 cis-3-oxo-8,9b-bis-(trans-N1-(acrylamidospermidyl))-1,2,3,4,4a,9b-hexahydrodibenzofuran
-
 Lunaria biennis
0.079
-
 (+/-)-10,11-dihydrolunarine
-
 Lunaria biennis
0.093
-
 cis-3-oxo-8,9b-bis-(trans-N3-(dimethylamino)propylacrylamido)-1,2,3,4,4a,9b-hexahydrodibenzofuran
-
 Lunaria biennis
0.096
-
 tetrahydrolunarine
-
 Lunaria biennis
0.101
-
 cis-3-(1,3-dioxolan-2-yl)-8-bromo-9b-(trans-acrylic acid)-1,2,3,4,4a,9b-hexahydrodibenzofuran
-
 Lunaria biennis
0.16
-
 numismine
-
 Lunaria biennis
0.218
-
 tetrahydrolunarinol
-
 Lunaria biennis
0.304
-
 lunarine
-
 Lunaria biennis
0.47
-
 lunarinol
-
 Lunaria biennis

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.029
-
 IC50: 0.029 mM Lunaria biennis cis-3-oxo-8,9b-bis-(trans-N-(acrylamidospermidyl))-1,2,3,4,4a,9b-hexahydrodibenzofuran
0.056
-
 IC50: 0.056 mM Lunaria biennis cis-3-oxo-8-trans-(N-acrylamidospermidyl)-9b-trans-ethylacrylyl-1,2,3,4,4a,9b-hexahydrodibenzofuran
0.065
-
 IC50: 0.065 mM Lunaria biennis lunarine