Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activity is dependent on a redox-active cysteine at the active centre | Trypanosoma cruzi |
Application | Comment | Organism |
---|---|---|
medicine | potential target for drug design against trypanosomiasis | Trypanosoma cruzi |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
6-chlorotacrine | competitive inhibition | Trypanosoma cruzi | |
9-Amino-1,2,3,4-tetrahydroacridine | i.e. tacrine, competitive inhibition | Trypanosoma cruzi | |
9-aminoacridine derivatives | competitive inhibition | Trypanosoma cruzi | |
9-thioacridine derivatives | mixed-type inhibition | Trypanosoma cruzi | |
Mepacrine | i.e. quinacrine, competitive inhibition | Trypanosoma cruzi |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
trypanothione + NADP+ = trypanothione disulfide + NADPH + H+ | mechanistic reaction scheme, structure-function relation | Trypanosoma cruzi |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH | - |
Trypanosoma cruzi | trypanothione + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TR | - |
Trypanosoma cruzi |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
25 | - |
assay at | Trypanosoma cruzi |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Trypanosoma cruzi | |
NADPH | - |
Trypanosoma cruzi |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.007 | 0.043 | 9-aminoacridine derivatives | - |
Trypanosoma cruzi | |
0.019 | - |
Mepacrine | - |
Trypanosoma cruzi | |
0.021 | 0.037 | 9-thioacridine derivatives | - |
Trypanosoma cruzi | |
0.08 | - |
6-chlorotacrine | - |
Trypanosoma cruzi | |
0.14 | - |
9-Amino-1,2,3,4-tetrahydroacridine | - |
Trypanosoma cruzi |