Literature summary for 1.8.1.12 extracted from

Bonse, S.; Richards, J.M.; Ross, S.A.; Lowe, G.; Krauth-Siegel, R.L.
(2,2':6',2''-Terpyridine)platinum(II) complexes are irreversible inhibitors of Trypanosoma cruzi trypanothione reductase but not of human glutathione reductase (2000), J. Med. Chem., 43, 4812-4821.

Search for more literature for 1.8.1.12

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	activity is dependent on a redox-active cysteine at the active centre	Trypanosoma cruzi

Inhibitors

Inhibitors	Comment	Organism	Structure
(4'-chloro-2,2':6',2''-terpyridine)platinum(II) ammine complex	irreversible, altering specifically the Cys52 residue in the active center, increased oxidase activity	Trypanosoma cruzi
(4-picoline) (4'-p-bromophenyl-2,2':6',2''-terpyridine)platinum(II) complex	irreversible, altering specifically the Cys52 residue in the active center, increased oxidase activity	Trypanosoma cruzi

Organism

Organism	UniProt	Comment	Textmining
Trypanosoma cruzi	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
trypanothione disulfide + NADPH	-	Trypanosoma cruzi	trypanothione + NADP+	-	?

Synonyms

Synonyms	Comment	Organism
TR	-	Trypanosoma cruzi

Cofactor

Cofactor	Comment	Organism	Structure
FAD	-	Trypanosoma cruzi
NADPH	-	Trypanosoma cruzi

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)