Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activity is dependent on a redox-active cysteine at the active centre | Crithidia fasciculata | |
additional information | activity is dependent on a redox-active cysteine at the active centre | Trypanosoma congolense |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.052 | - |
N-benzyloxycarbonyl-L-cysteinylglycyl-3-dimethylaminopropylamide disulfide | - |
Crithidia fasciculata | |
0.225 | - |
L-gamma-glutamyl-L-cysteinylglycyl-3-dimethylaminopropylamide disulfide | - |
Crithidia fasciculata | |
0.251 | - |
tert-butyloxycarbonyl-L-cysteinylglycyl-3-dimethylaminopropylamide disulfide | - |
Crithidia fasciculata | |
0.448 | - |
4-aminobutyryl-L-cysteinylglycyl-3-dimethylaminopropylamide disulfide | - |
Crithidia fasciculata | |
0.693 | - |
L-beta-aspartyl-L-cysteinylglycyl-3-dimethylaminopropylamide disulfide | - |
Crithidia fasciculata | |
0.968 | - |
L-cysteinylglycyl-3-dimethylaminopropylamide disulfide | - |
Crithidia fasciculata |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH | Crithidia fasciculata | - |
trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH | Trypanosoma congolense | - |
trypanothione + NADP+ | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Crithidia fasciculata | - |
- |
- |
Trypanosoma congolense | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
trypanothione + NADP+ = trypanothione disulfide + NADPH + H+ | neither the alpha-carboxy nor the alpha-amino function of the L-gamma-glutamyl group is essential for activity, can be replaced by uncharged benzyloxycarbonyl or tert-butyloxycarbonyl groups | Crithidia fasciculata | |
trypanothione + NADP+ = trypanothione disulfide + NADPH + H+ | substrate binding structure, structural model | Trypanosoma congolense |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-aminobutyryl-L-cysteinylglycyl-3-dimethylaminopropylamide disulfide + NADPH + H+ | substrate analogue | Crithidia fasciculata | 2 N-(4-aminobutanoyl)-L-cysteinyl-N-[3-(dimethylamino)propyl]glycinamide + NADP+ | - |
? | |
L-beta-aspartyl-L-cysteinylglycyl-3-dimethylaminopropylamide disulfide + NADPH + H+ | substrate analogue | Crithidia fasciculata | 2 L-beta-aspartyl-L-cysteinyl-N-[3-(dimethylamino)propyl]glycinamide + NADP+ | - |
? | |
L-cysteinylglycyl-3-dimethylaminopropylamide disulfide + NADPH + H+ | substrate analogue | Crithidia fasciculata | 2 L-cysteinyl-N-[3-(dimethylamino)propyl]glycinamide + NADP+ | - |
? | |
L-gamma-glutamyl-L-cysteinylglycyl-3-dimethylaminopropylamide disulfide + NADPH + H+ | substrate analogue | Crithidia fasciculata | 2 L-gamma-glutamyl-L-cysteinyl-N-[3-(dimethylamino)propyl]glycinamide + NADP+ | - |
? | |
additional information | glutaryl-L-cysteinylglycyl-3-methylaminopropylamide disulfide is no substrate | Crithidia fasciculata | ? | - |
? | |
N-benzyloxycarbonyl-L-cysteinylglycyl-3-dimethylaminopropylamide disulfide + NADPH + H+ | substrate analogue | Crithidia fasciculata | 2 N-[(benzyloxy)carbonyl]-L-cysteinyl-N-[3-(dimethylamino)propyl]glycinamide + NADP+ | - |
? | |
tert-butyloxycarbonyl-L-cysteinylglycyl-3-dimethylaminopropylamide disulfide + NADPH + H+ | substrate analogue | Crithidia fasciculata | 2 N-(tert-butoxycarbonyl)-L-cysteinyl-N-[3-(dimethylamino)propyl]glycinamide + NADP+ | - |
? | |
trypanothione disulfide + NADPH | - |
Crithidia fasciculata | trypanothione + NADP+ | - |
? | |
trypanothione disulfide + NADPH | - |
Trypanosoma congolense | trypanothione + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TR | - |
Crithidia fasciculata |
TR | - |
Trypanosoma congolense |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
21.8 | - |
4-aminobutyryl-L-cysteinylglycyl-3-dimethylaminopropylamide disulfide | - |
Crithidia fasciculata | |
53.2 | - |
L-cysteinylglycyl-3-dimethylaminopropylamide disulfide | - |
Crithidia fasciculata | |
61.3 | - |
L-beta-aspartyl-L-cysteinylglycyl-3-dimethylaminopropylamide disulfide | - |
Crithidia fasciculata | |
101 | - |
tert-butyloxycarbonyl-L-cysteinylglycyl-3-dimethylaminopropylamide disulfide | - |
Crithidia fasciculata | |
109 | - |
N-benzyloxycarbonyl-L-cysteinylglycyl-3-dimethylaminopropylamide disulfide | - |
Crithidia fasciculata | |
818 | - |
L-gamma-glutamyl-L-cysteinylglycyl-3-dimethylaminopropylamide disulfide | - |
Crithidia fasciculata |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Crithidia fasciculata | |
FAD | - |
Trypanosoma congolense | |
NADPH | - |
Crithidia fasciculata | |
NADPH | - |
Trypanosoma congolense |