Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | activity is dependent on a redox-active cysteine at the active centre | Crithidia fasciculata |
General Stability | Organism |
---|---|
loss of 39% activity after incubation with NADPH at 25°C | Crithidia fasciculata |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
arsenite | + NADPH, slightly | Crithidia fasciculata | |
cymelarsen | + NADPH | Crithidia fasciculata | |
Melarsen oxide | inhibition is increased in presence of NADPH, inhibition is abolished by melarsen-trypanothione disulfide adduct | Crithidia fasciculata | |
melarsen-trypanothione disulfide adduct | no inhibition | Crithidia fasciculata | |
melarsoprol | + NADPH, slightly | Crithidia fasciculata | |
NADPH | NADPH inhibits the enzyme at higher concentration and during longer incubation times, enzyme can be protected by NADP+ | Crithidia fasciculata | |
phenylarsenoxide | + NADPH | Crithidia fasciculata |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Crithidia fasciculata | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Crithidia fasciculata |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
247 | - |
purified enzyme | Crithidia fasciculata |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
trypanothione disulfide + NADPH | - |
Crithidia fasciculata | trypanothione + NADP+ | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TR | - |
Crithidia fasciculata |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
27 | - |
assay at | Crithidia fasciculata |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.8 | - |
assay at | Crithidia fasciculata |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
FAD | - |
Crithidia fasciculata | |
NADPH | - |
Crithidia fasciculata |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.016 | - |
Melarsen oxide | with melarsen-trypanothione disulfide-adduct | Crithidia fasciculata | |
0.0172 | - |
Melarsen oxide | with NADPH | Crithidia fasciculata |