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Literature summary for 1.7.99.4 extracted from

  • Rowley, G.; Hensen, D.; Felgate, H.; Arkenberg, A.; Appia-Ayme, C.; Prior, K.; Harrington, C.; Field, S.J.; Butt, J.N.; Baggs, E.; Richardson, D.J.
    Resolving the contributions of the membrane-bound and periplasmic nitrate reductase systems to nitric oxide and nitrous oxide production in Salmonella enterica serovar Typhimurium (2012), Biochem. J., 441, 755-762.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining

General Information

General Information Comment Organism
physiological function under nitrate-rich conditions, the nar and nap genes encoding a membrane-bound form and a periplasmic form of nitrate reductase, as well as NO-regulated genes encoding flavohaemoglobin, flavorubredoxin and hybrid cluster protein are induced following transition from the oxic to anoxic state, and 20% of nitrate consumed in steady-state is released as N2O when nitrite has accumulated to millimolar levels. The kinetics of nitrate consumption, nitrite accumulation and N2O production are similar to those of wild-type in nitrate-sufficient cultures of a nap mutant. Under nitrate-limited conditions, periplasmic enzyme nap, but not nar, is upregulated following transition from oxic to anoxic metabolism and very little N2O production was observedA combination of nitrate-sufficiency, nitrite accumulation and an active Nar-type nitrate reductase leads to NO and thence N2O production, and this can account for up to 20% of the nitrate catabolized Salmonella enterica subsp. enterica serovar Typhimurium