Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 1.7.5.1 extracted from

  • Zhao, Z.; Rothery, R.A.; Weiner, J.H.
    Transient kinetic studies of heme reduction in Escherichia coli nitrate reductase A (NarGHI) by menaquinol (2003), Biochemistry, 42, 5403-5413.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2-n-heptyl-4-hydroxyquinoline N-oxide quinol-binding-site inhibitor, elicits a much stronger inhibitory effect than stigmatellin on the reoxidation of the hemes Escherichia coli
Stigmatellin quinol-binding-site inhibitor Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
nitrate + 2-methyl-1,4-naphthoquinol i.e. menadiol Escherichia coli nitrite + 2-methyl-1,4-naphthoquinone + H2O
-
?

Synonyms

Synonyms Comment Organism
NarGHI
-
Escherichia coli
nitrate reductase A
-
Escherichia coli

Cofactor

Cofactor Comment Organism Structure
heme the reduction of NarGHI hemes by menaquinol, the reduction exhibits four phases, a transient species associated with the enzyme is kinetically correlated to the second reduction of the hemes Escherichia coli
menaquinone there are more than one menaquinol binding sites in NarGHI Escherichia coli