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Literature summary for 1.6.5.5 extracted from

  • Nutter, L.M.; Ngo, E.O.; Fisher, G.R.; Gutierrez, P.L.
    DNA strand scission and free radical production in menadione-treated cells. Correlation with cytotoxicity and role of NADPH quinone acceptor oxidoreductase (1992), J. Biol. Chem., 267, 2474-2479.
    View publication on PubMed
Search for more literature for 1.6.5.5

Application

Application Comment Organism
medicine QAO does not possess a protective role in menadione-induced free radical production and DNA damage in human cancer cells. Under aerobic conditions, menadiol produced by QAR is readily oxidized to menadione by two 1-electron steps producing the semiquinone and the parent quinone with concomitant production of superoxide anion, which leads to generation of hydroxyl radicals Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
dicoumarol presence of dicoumarol decreases the production of hydroxyl radical and attenuates DNA strand-breaks in MCF-7 cells treated with menadione Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
menadione + NADPH + H+
-
 Homo sapiens menadiol + NADP+ under aerobic conditions, menadiol is readily oxidized to menadione by two 1-electron steps producing the semiquinone and the parent quinone with concomitant production of superoxide anion, which leads to generation of hydroxyl radicals ?

Synonyms

Synonyms Comment Organism
NADPH quinone acceptor oxidoreductase
-
 Homo sapiens
QAO
-
 Homo sapiens