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Literature summary for 1.6.5.5 extracted from

  • Uchiyama, N.; Kabututu, Z.; Kubata, B.K.; Kiuchi, F.; Ito, M.; Nakajima-Shimada, J.; Aoki, T.; Ohkubo, K.; Fukuzumi, S.; Martin, S.K.; Honda, G.; Urade, Y.
    Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme (2005), Antimicrob. Agents Chemother., 49, 5123-5126.
    View publication on PubMedView publication on EuropePMC

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.013
-
nifurtimox
-
Trypanosoma cruzi
0.019
-
menadione
-
Trypanosoma cruzi
0.03
-
komaroviquinone
-
Trypanosoma cruzi

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
Trypanosoma cruzi 5737
-

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
amastigote the enzyme is expressed throughout the Trypanosoma cruzi life cycle Trypanosoma cruzi
-
epimastigote the enzyme is expressed throughout the Trypanosoma cruzi life cycle Trypanosoma cruzi
-
trypomastigote the enzyme is expressed throughout the Trypanosoma cruzi life cycle Trypanosoma cruzi
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADPH + H+ + komaroviquinone reduction of komaroviquinone to its semiquinone radical. Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme Trypanosoma cruzi NADP+ + ?
-
?
NADPH + H+ + menadione
-
Trypanosoma cruzi NADP+ + ?
-
?
NADPH + H+ + nifurtimox
-
Trypanosoma cruzi NADP+ + ?
-
?

Synonyms

Synonyms Comment Organism
old yellow enzyme
-
Trypanosoma cruzi
TcOYE
-
Trypanosoma cruzi

Cofactor

Cofactor Comment Organism Structure
NADPH
-
Trypanosoma cruzi