KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.013 | - |
nifurtimox | - |
Trypanosoma cruzi | |
0.019 | - |
menadione | - |
Trypanosoma cruzi | |
0.03 | - |
komaroviquinone | - |
Trypanosoma cruzi |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytoplasm | - |
Trypanosoma cruzi | 5737 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trypanosoma cruzi | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amastigote | the enzyme is expressed throughout the Trypanosoma cruzi life cycle | Trypanosoma cruzi | - |
epimastigote | the enzyme is expressed throughout the Trypanosoma cruzi life cycle | Trypanosoma cruzi | - |
trypomastigote | the enzyme is expressed throughout the Trypanosoma cruzi life cycle | Trypanosoma cruzi | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADPH + H+ + komaroviquinone | reduction of komaroviquinone to its semiquinone radical. Antichagasic activity of komaroviquinone is due to generation of reactive oxygen species catalyzed by Trypanosoma cruzi old yellow enzyme | Trypanosoma cruzi | NADP+ + ? | - |
? | |
NADPH + H+ + menadione | - |
Trypanosoma cruzi | NADP+ + ? | - |
? | |
NADPH + H+ + nifurtimox | - |
Trypanosoma cruzi | NADP+ + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
old yellow enzyme | - |
Trypanosoma cruzi |
TcOYE | - |
Trypanosoma cruzi |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADPH | - |
Trypanosoma cruzi |