Literature summary for 1.6.5.4 extracted from

Begara-Morales, J.C.; Sanchez-Calvo, B.; Chaki, M.; Mata-Perez, C.; Valderrama, R.; Padilla, M.N.; Lopez-Jaramillo, J.; Luque, F.; Corpas, F.J.; Barroso, J.B.
Differential molecular response of monodehydroascorbate reductase and glutathione reductase by nitration and S-nitrosylation (2015), J. Exp. Bot., 66, 5983-5996 .

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Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	presence of 0.5 or 2 mM glutathione does neither inhibit nor activate the enzyme	Pisum sativum

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Pisum sativum

Protein Variants

Protein Variants	Comment	Organism
Y345F	mutant is a functional enzyme resistant to inhibition by 0.5 mM and 5.0 mM peroxynitrite	Pisum sativum

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	presence of 0.5 or 2 mM glutathione does neither inhibit nor activate the enzyme	Pisum sativum
peroxynitrite	exclusively nitrates residues Tyr213, Try292, and Tyr345. Tyr345 is found at 3.3 A of His313, which is involved in the NADP-binding site. Nitration of residue Tyr345 is responsible for inhibition	Pisum sativum
S-nitrosoglutathione	0.5 and 2 mM, 58% and 65% inhibition, respectively	Pisum sativum

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
peroxisome	-	Pisum sativum	5777	-

Organism

Organism	UniProt	Comment	Textmining
Pisum sativum	Q66PF9	-	-

Synonyms

Synonyms	Comment	Organism
MDHAR1	-	Pisum sativum

Expression

Organism	Comment	Expression
Pisum sativum	MDAR expression (mRNA, protein, and enzyme activity levels) increase upon treatment with 150 mM NaCl	up

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Release 2023.1 (January 2023)