Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | P05982 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
pancreas | - |
Rattus norvegicus | - |
pancreatic islet | - |
Rattus norvegicus | - |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | in pancreatic beta-cells, NQR1 primarily utilizes NADH | Rattus norvegicus |
Organism | Comment | Expression |
---|---|---|
Rattus norvegicus | basal expression of NQO1 and NADPH cytochrome P450 oxidoreductase is comparable in isolated islets and liver | additional information |
Rattus norvegicus | NQO1, but not NADPH cytochrome P450 oxidoreductase , is strongly induced in pancreatic beta-cells exposed to menadione | up |
General Information | Comment | Organism |
---|---|---|
physiological function | in addition to protection of b-cells from toxic concentrations of the redox cycling quinone menadione, NQO1 also regulates the basal level of reduced-to-oxidized nucleotides | Rattus norvegicus |