Literature summary for 1.6.5.2 extracted from

Kasai, S.; Arakawa, N.; Okubo, A.; Shigeeda, W.; Yasuhira, S.; Masuda, T.; Akasaka, T.; Shibazaki, M.; Maesawa, C.
NAD(P)H quinone oxidoreductase-1 expression sensitizes malignant melanoma cells to the HSP90 inhibitor 17-AAG (2016), PLoS ONE, 11, e0153181 .

Search for more literature for 1.6.5.2

Application

Application	Comment	Organism
medicine	NQO1 is highly expressed in normal melanocytes and in several melanoma cell lines in the presence of wild-type KEAP1, whose mutation elicits constitutive NRF2 activation and resistance to cisplatin. NQO1 expression is dependent on NRF2 activation. Synergistic cytotoxicity of HSP90 inhibitor 17-AAG, i.e. 17-(allylamino)-17-demethoxygeldanamycin, and cisplatin is detected in four out of five NQO1-low cell lines, but not in a cell line with KEAP1 mutation	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P15559	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
melanoma cell	-	Homo sapiens	-
non-small cell lung carcinoma cell	-	Homo sapiens	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)