Literature summary for 1.6.5.2 extracted from

Okubo, A.; Yasuhira, S.; Shibazaki, M.; Takahashi, K.; Akasaka, T.; Masuda, T.; Maesawa, C.
NAD(P)H dehydrogenase, quinone 1 (NQO1), protects melanin-producing cells from cytotoxicity of rhododendrol (2016), Pigment cell Melanoma Res., 29, 309-316 .

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Inhibitors

Inhibitors	Comment	Organism	Structure
ES936	-	Homo sapiens
ES936	-	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P15559	-	-
Mus musculus	Q64669	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
B16-BL6 cell	-	Mus musculus	-
melanocyte	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	treatment of normal human melanocytes with carnosic acid, a transcriptional inducer of the NQO1 gene, notably suppresses the cell killing effect of tyrosinase inhibitor rhododendrol. The effect is mostly abolished by ES936, a highly specific NQO1 inhibitor. Conditional overexpression of the human NQO1 transgene in mouse B16BL6 cells leads to an expression-dependent increase of cell survival after rhododendrol treatment	Homo sapiens
physiological function	treatment of the mouse melanoma cell line B16-BL6 with carnosic acid, a transcriptional inducer of the NQO1 gene, notably suppresses the cell killing effect of tyrosinase inhibitor rhododendrol. The effect is mostly abolished by NQO1 inhibitor ES936	Mus musculus

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Release 2023.1 (January 2023)